Drug discovery company BellBrook Labs has been awarded a $300,000 Phase I Small Business Innovative Research grant to develop and validate HTS assays for the discovery of small-molecule antagonists of TREX1.
Immunotherapy approaches such as immune checkpoint blockade are said to be transforming oncology. However, many patients do not respond to existing agents, and new therapeutic strategies for eliciting immune responses to tumours are required.
It has recently become clear that activation of the stimulator of interferon (IFN) genes (STING) pathway is a critical step for initiating an antitumour T cell response in the tumour microenvironment (TME). TREX1 acts as a checkpoint on tumour cell immunity by preventing activation of the STING pathway in tumour cells. Upregulation of TREX1 by radiotherapy and chemotherapy interferes with their in situ vaccination effects. Multiple lines of evidence indicate that TREX1 antagonists could represent a new class of immune checkpoint blockers with broad and fundamental impact on cancer treatment regimens.
To enable the discovery of small molecule TREX1 antagonists, BellBrook says it will leverage its proprietary Transcreener HTS Assay platform to develop and validate a robust, quantitative high throughput TREX1 enzymatic assay as a critical tool for screening and lead optimization. It will also validate a virtual screening approach for TREX1 in collaboration with SilcsBio (Baltimore, MD), a leading-edge computer-aided drug design company.
Image credit: Chronis Yan