Assay

Some 5% of commercially available research compounds are sold as salt forms. These can have better properties than their parents, including preferable stability, solubility, bioavailability, and manufacturability. By selecting the correct salt form for an assay or as a reagent, scientists can optimise their research projects, says Andrievs Auseklis Auzin, Developer, Molport, Latvia. The research […]

This whitepaper brought to you by Mirus Bio details the multiple approaches developers can use to verify the quality and functionality of viral assays. Download the latest Mirus Bio whitepaper to learn about: Methods to characterize lentivirus and adeno-associated virus Differences between physical and functional assays of virus How to perform an infectivity assay to […]

News round-up by DDW’s Reece Armstrong for 27 – 30 June. Assays for monkeypox, Covid-19 boosters and approvals for oncology drugs are some of the themes of this week’s news round-up. GSK & Sanofi first to report positive data for Omicron booster   GSK and Sanofi have reported positive efficacy data from a co-developed vaccine targeting […]

Clinical diagnostics company Novacyt has launched a polymerase chain reaction (PCR) monkeypox assay in response to the recent outbreak of the virus non-endemic countries.   The company’s monkeypox assay is for research-use only (RUO) and has been developed in two forms for the detection of the virus genome in both of its West African and Central African […]

Life sciences provider Axol Bioscience has announced that its human induced pluripotent stem cell (iPSC)-derived ventricular cardiomyocytes have undergone comprehensive in vitropro-arrhythmia assay (CiPA) validation. By using this assay, Axol was able to show that the cells were suitable for measuring cardiotoxicity, offering scientists a robust cardiac model for drug discovery and screening.   Axol’s human iPSC-derived […]

Gentronix, a UK-based contract research organisation (CRO) working in the field of genetic toxicology, has raised £700,000 in a funding round led by existing investor Mercia to support its continued growth.  The latest round, which includes a number of private investors, follows Gentronix’s recent acquisition of the Big Blue transgenic mutation assay from Merck KGaA. It will be used […]

This paid-for advertorial by CDD Vault appeared in the DDW / ELRIG UK Drug Discovery 2021 supplement in DDW Volume 22, Issue 4 – Fall 2021   For any research-based organisation in the life sciences arena, experimental data is the key to deriving biological and biochemical insight and understanding, and ultimately driving product development. The ability to […]

Using Promega’s NanoBRET technology, scientists at Aurelia Bioscience have implemented intracellular kinase assays designed to study the interaction of compounds on kinase targets in intact living cells. Advantages of this technique include examination of compound binding to target kinases at physiological ATP concentrations, expression of full-length kinase target in cells, disruption of cells (with digitonin) […]

Pelago Bioscience is a specialised CRO, focusing on its patented Cellular Thermal Shift Assay (CETSA), which can assess therapeutically relevant target engagement in cells or tissue of unmodified compounds against the native, full-length proteins of interest. Stina Lundgren, Principal Project Advisor, shared the company’s hit-to-lead expertise with Lu Rahman. CETSA by Pelago can be adapted […]

There is an unmet clinical need in drug development for in vitro models that reduce the risk of drug-induced toxicity and late-stage drug attrition. In this webinar, hosted on May 26 2021, two expert speakers discuss how researchers can enhance the predictability of pre-clinical drug development. This webinar, Enhancing the predictability of preclinical development, hosted by DDW […]