In a study published in Neurology, a group from Alnylam Pharmaceuticals used large-scale protein screening assays to simultaneously analyse many proteins in vast numbers of patient serum samples. This approach allowed them to discover a novel biomarker of hereditary transthyretin-mediated (ATTRv) amyloidosis disease onset and progression. ATTRv amyloidosis, caused by mutation of the transthyretin protein is […]

In a study published in Neurology, a group from Alnylam Pharmaceuticals used large-scale protein screening assays to simultaneously analyse many proteins in vast numbers of patient serum samples. This cutting-edge approach allowed them to discover a novel biomarker of hereditary transthyretin-mediated (ATTRv) amyloidosis disease onset and progression. ATTRv amyloidosis, caused by mutation of the transthyretin […]

Research laboratories have not fundamentally changed since the 1960s, says BMG LABTECH. Despite improvements in technology such as high-throughput screening and computational drug design, drug discovery is becoming slower and more expensive over time. Covid-19 highlighted operational vulnerabilities which are driving a fundamental reassessment of strategic priorities. In fact, says the company, researchers spend a […]

Evaluation of checkpoint inhibitor therapies using an MLR assay, is an exclusive webinar that will be hosted by DDW and supported by Sartorius. It will provide valuable information for immuno-oncology research and the cancer immunotherapy drug discovery process. The event is now available to watch on demand here Sartorius recognises that conventional techniques for analysis of […]

One of the key elements of quality control in pharmaceutical manufacturing is cGMP compliance. As your product moves closer to market, cGMP requirements change and become more stringent. Dalton Pharma Services has created a whitepaper to download, FDA Guidelines for GMP of API. Featured in this whitepaper which you can download here: API and GMP […]

One of the key elements of quality control in pharmaceutical manufacturing is cGMP compliance. As your product moves closer to market, cGMP requirements change and become more stringent. Dalton Pharma Services has created a whitepaper to download, FDA Guidelines for GMP of API. Featured in this whitepaper: API and GMP overview FDA API regulations including: […]

Covid-19 has highlighted the current operational vulnerabilities in pharmaceutical research and in the drug discovery pipeline. Bringing new drugs to the market is still a slow and expensive process, with far too high costs, failure rates and cycle times. With low reproducibility and inefficient processes delaying the path to approval, the pandemic is prompting a […]

Covid-19 has highlighted the current operational vulnerabilities in pharmaceutical research and in the drug discovery pipeline. Bringing new drugs to the market is still a slow and expensive process, with far too high costs, failure rates and cycle times. With low reproducibility and inefficient processes delaying the path to approval, the pandemic is prompting a […]

The pressure to take your drug to market faster is increasing. To achieve a successful journey to the first clinical trial phase in the fastest time possible, Eppendorf has identified three key elements that it is addressing in an eBook.  Comply with audit requirements and relevant certifications  Drive process efficiencies with increased speed whilst not […]

The pressure to take your drug to market faster is increasing. To achieve a successful journey to the first clinical trial phase in the fastest time possible, we have identified three key elements we are addressing in this eBook. Comply with audit requirements and relevant certifications Drive process efficiencies with increased speed whilst not sacrificing […]

There is an unmet clinical need in drug development for in vitro models that reduce the risk of drug-induced toxicity and late-stage drug attrition. In this webinar, hosted on May 26 2021, two expert speakers discuss how researchers can enhance the predictability of pre-clinical drug development. This webinar, Enhancing the predictability of preclinical development, hosted by DDW […]

The development of predictive preclinical assays is key to success in drug development. It is therefore critical to carefully construct biomarker studies using the most appropriate assays that better represent the complex physiology of disease for the reliable assessment of safety, efficacy, and dose predictions. To explore this topic further, Dr. Hyelim Cho, Group Lead, Immunogenicity, Global DMPK Oncology and Rare Diseases, Takeda Pharmaceuticals discusses translational immuno-oncology assay development in […]

The Olympus Provi CM20 incubation monitoring system can be used to develop methods for efficient quality control and data management within your cell culture workflow. The company has created an application note which will allow you to understand how the quantitative data collected from the CM20 enabled users to compare and detect variable efficiency of […]

The OLYMPUS Provi CM20 incubation monitoring system can be used to develop methods for efficient quality control and data management within your cell culture workflow. In this application note, discover how the quantitative data collected from the CM20 enabled users to compare and detect variable efficiency of differentiation of Human iPS cell lines for generation […]

The latest DDW Sitting Down With podcast features Anders Mälarstig, Director of Human Genetics, Pfizer. In this podcast he outlines the role of pQTLs in the drug discovery process and the growing importance of proteogenomics Mälarstig  is currently responsible for developing and applying strategies for new drug targets and precision medicine. He has extensive experience […]

Immunotherapy has the potential to treat a wide variety of conditions, from autoimmune disease to cancer. However, the discovery of potential antibody therapeutics against key receptor proteins remains a major challenge for the traditional immunisation approaches currently available on the market. Twist Biopharma, an arm of Twist Bioscience, was built to overcome this bottleneck by […]