Afucosylated mAb expression benefits therapeutic antibody efficacy

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Currently, at least 35 glycoengineered antibodies, with their Fc fucose partially or entirely removed, have been investigated in animal models or clinical trials.

The absence of fucose on the Fc N-glycan increases IgG1 Fc binding affinity to the FcγRIIIa on immune effector cells like natural killer cells. It results in increased antibody-dependent cellular cytotoxicity (ADCC).

Sino Biological’s “FucoFree” eukaryotic expression system provides high-yield and high-throughput afucosylated mAb production.

Download this app note to learn more about:

  • How antibodies work to eliminate the antigens
  • How to lower the fucosylation on Fc
  • “FucoFree” system for high-yield and high-throughput afucosylated mAb expression

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