Video: Micro Tissues on Electrospun Scaffolds

In this video, Dr Gary Allenby, CEO Aurelia Bioscience, describes a scientific poster on ‘Magnetic Electrospun Micro-fibre Scaffold Assemblies: Examples of their use for 3-Dimensional Cell-Based Screening Applications’.

How the technology works:

  • Aurelia Bioscience has developed a 3-D micro-tissue system from electrospun material that can be used in conjunction with well plates for higher throughput screening
  • Electrospun material mimics the natural extracellular matrix and provides an ideal substrate for cells to adhere to
  • Scientists at Aurelia Bisocience have re-engineered electrospun material to form micro-scaffold islands on to which we seed, grow and differentiate cells prior to performing more conventional assays in well plates. Cells grow on, around and into the material, forming a micro-island of adherent cells that are effectively “micro-tissues in solution”
  • The incorporation of iron particles into fibres during manufacture results in scaffolds that can be physically manipulated using magnetism
  • The incorporation of fluorescence dyes into fibres during manufacture means that fibres can be seen when imaging and can be used as a ‘barcode’ – two colours can be used to distinguish different cells types or populations in the same well

Advantages of this technology:

  • Robust and reproducible 3-D culture environment
  • Applicable to any cell type (recombinant, human primary cells and iPSC’s plus differentiation)
  • Movable: from vessels-to-well and well-to-well with magnetism
  • Scalable to any assay throughput
  • Integrates seamlessly with all current screening and assay workflows

Follow the link to download the poster.

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