In this video, Dr Gary Allenby, CEO Aurelia Bioscience, describes a scientific poster on ‘Magnetic Electrospun Micro-fibre Scaffold Assemblies: Examples of their use for 3-Dimensional Cell-Based Screening Applications’.
How the technology works:
- Aurelia Bioscience has developed a 3-D micro-tissue system from electrospun material that can be used in conjunction with well plates for higher throughput screening
- Electrospun material mimics the natural extracellular matrix and provides an ideal substrate for cells to adhere to
- Scientists at Aurelia Bisocience have re-engineered electrospun material to form micro-scaffold islands on to which we seed, grow and differentiate cells prior to performing more conventional assays in well plates. Cells grow on, around and into the material, forming a micro-island of adherent cells that are effectively “micro-tissues in solution”
- The incorporation of iron particles into fibres during manufacture results in scaffolds that can be physically manipulated using magnetism
- The incorporation of fluorescence dyes into fibres during manufacture means that fibres can be seen when imaging and can be used as a ‘barcode’ – two colours can be used to distinguish different cells types or populations in the same well
Advantages of this technology:
- Robust and reproducible 3-D culture environment
- Applicable to any cell type (recombinant, human primary cells and iPSC’s plus differentiation)
- Movable: from vessels-to-well and well-to-well with magnetism
- Scalable to any assay throughput
- Integrates seamlessly with all current screening and assay workflows
Follow the link to download the poster.
