The latest free-to-listen DDW podcast episode is titled “Using biotechnology to maximise drug discovery output”. It covers two articles written for Volume 22, Issue 2 – Spring 2021 of the Drug Discovery World Magazine and has been narrated by DDW’s Megan Thomas.
These articles are titled: “The important integration of medicinal chemistry in Hit-to-Lead discovery” and “With so many technologies for genetically modifying models, it pays to choose wisely”.
High-throughput screens are a recognised hit-finding process but the use of an integrated discipline approach is key to maximising the output from such a screening methodology. In the first article, Ian Linney and Scott Maidment from Charles River describe the value of integration of medicinal chemistry in this method.
Thanks to continued advances in genetic engineering, investigators often find they can obtain the most relevant mouse model for their research by commissioning the custom generation of a model that best meets their need—whether it’s modelling a disease state, validating a gene target of interest, or testing a drug candidate in vivo. Caroline Horizny from Taconic Biosciences discusses this in the second article.