Heart disease

ARMGO Pharma has enrolled the first patient in a Phase II proof-of-concept clinical trial using its Rycal ARM210 (also known as S48168), for the treatment of catecholaminergic polymorphic ventricular tachycardia (CPVT). The trial, performed at the Amsterdam University Medical Center (Amsterdam UMC), Netherlands and the Mayo Clinic, Rochester MN, USA will investigate the safety and […]

A National Institutes of Health (NIH) clinical trial was stopped early because a daily statin medication was found to reduce the increased risk of cardiovascular disease among people living with HIV. This was the first large-scale clinical study to test a primary cardiovascular prevention strategy in this population. Advances in HIV treatment have drastically reduced […]

The first subjects have been dosed in a Phase I clinical trial of VXX-401, an investigational vaccine designed to lower low-density lipoprotein (LDL) cholesterol, a known factor in heart disease. The drug works by targeting proprotein convertase subtilisin/kexin type 9 serine protease (PCSK9). “We’re excited to get this first-in-human trial of VXX-401 started. The concept […]

The UK’s Medicines and Healthcare products Regulatory Agency (MHRA) has granted a licence extension for dapagliflozin for the treatment of symptomatic chronic heart failure (HF).  The drug is approved in patients with HF and a left ventricular ejection fraction (LVEF) >40%, including HF with mildly reduced ejection fraction (HFmrEF) and preserved ejection fraction (HFpEF).  HF […]

An international team of researchers has won £30 million for its work in developing a potential cure for inherited heart muscle conditions in young people.  CureHeart was selected as the winner of the British Heart Foundation’s (BHF) Big Beat Challenge, which grants a £30 million non-commercial grant to the winner.   CureHeart is using gene therapy […]

Australian biopharmaceutical company Cholrem have produced CAVADEX (Beta-Cyclodextrin), a product which removes cholesterol from damaged and narrowed arteries after a few months of treatment, leading to increased blood flow.  Context  Atherosclerosis, also known as heart disease, is reportedly the western world’s number one killer of people. This disease results from the accumulation of cholesterol in the arteries. […]