Single-cell Sequencing 101: DNA & Multi-omics for Precision Medicine

Cancer is a complex disease that continuously evolves in response to environmental pressures. The dynamism and heterogeneity of tumours have significant clinical implications. In this eBook, we review how single-cell DNA sequencing and multi-omics are used to dissect clonal architecture, providing valuable insights for clinical strategies, disease modelling, and the development of cell and gene therapies.

Specifically, we cover:

  • The clonal evolution of cancer
  • Linking genotype & phenotype with multi-omics
  • Translational applications for the clinic
  • Single-cell analysis of genome engineering

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