A new Whitepaper is available from Thermo Fisher Scientific, entitled ‘Lentiviral vector characterization for cell and gene therapy manufacturing using the QuantStudio Absolute Q Digital PCR System’.
Recombinant lentiviral vectors are used for ex vivo transgene delivery in several gene-modified cell therapies, such as chimeric antigen receptor (CAR) T cell therapy.
Reliable analytical methods such as digital PCR to characterise lentiviral vectors and the cells transduced with them are critical to helping ensure the safety and efficacy of these biologics.
Download this new Whitepaper to learn about:
- Use of ViralSEQ Lentivirus Physical and Proviral DNA Titer Kits with the QuantStudio Absolute QDigital PCR System
- Measurement of lentiviral vector titers and provirus copies in transduced cells by digital PCR
- Long terminal repeat (LTR)-based quantitation enabling correlation of total (genomic) and infectious viral particles