Leaving the Wild West Era of Lipidomics

Leading research from European Journal of Lipid Science and Technology How many different types of diseases are there in the world? How will we ever be able to find cures for them? We might not be able to do so for all of them, but we may be able to develop better treatments. Scientific and technological advancements are making it easier to understand the causes of and physiological processes of diseases and how molecular and biochemical aspects of lipids play a role. Due to its promising application for identifying and quantifying lipids as biomarkers of disease, lipidomics research has advanced considerably in recent years. Moreover, lipids are successfully used in pharmaceutical products to treat diseases. Avanti® offers a broad range of high-quality lipids that can be used as standards in lipidomic studies. In this edition, a comparison of the production, use and properties of natural and synthetic phospholipids as pharmaceutical excipients is made by Hoogevest and Wendel. Kim et al. study deformable liposomes as potential carriers for transdermal drug delivery. Martinović et al. explore how sinapic acid and its derivatives strengthen oxidative stability in different lipid systems. The effects of lipid oxidation-derived aldehyde and oxysterols on health and disease is discussed by Sottero et al. Surma el al. present an automated shotgun lipodomics platform for high throughput, comprehensive, and quantitative analysis of intact blood plasma lipids. As you can see, significant progress is being made in lipidomics research! CONTENT OVERVIEW Page 3 Editorial Page 5 Insights in Disease Research Using Lipid Biochemistry Page 8 The Use of Natural and Synthetic Phospholipids as Pharmaceutical Excipients van Hoogevest P., Wendel A. Page 14 Preparation, Physical Characterization, and In Vitro Skin Permeation of Deformable Liposomes Loaded with Taxifolin and Taxifolin Tetraoctanoate Kim A. R., An H. J., Jang E. S. et al. Page 18 Sinapic Acid and its Derivatives Increase Oxidative Stability in Different Model Lipid Systems Martinović N., Poklar Ulrih N., Abramovič H. Page 22 The Effects of Lipid Oxidation-Derived Aldehyde and Oxysterols on Health and Disease Sottero B., Leonarduzzi G., Testa G. et al. Page 27 An Automated Shotgun Lipidomics Platform for High Throughput, Comprehensive, and Quantitative Analysis of Blood Plasma Intact Lipids Surma M. A., Herzog R., Vasilj A. et al. Page 32 A Progress Report on Five Decades of Lipid Mass Spectrometry Robert C. Murphy

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Leaving the Wild West Era of Lipidomics

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