Illumina and Merck have partnered to develop and commercialise tests that identify genetic mutations used in the assessment of homologous recombination deficiency (HRD).
Patients whose tumours are HRD-positive may be eligible for targeted treatment by a class of precision medicines called PARP inhibitors. The HRD tests will leverage Illumina’s TruSight Oncology 500 (TSO 500) content, enabling genomic profiling assays in a single workflow.
This strategic partnership builds on an initial study conducted with Merck and leverages Illumina’s relationship with Myriad Genetics to expand international access to the proprietary technology in Myriad’s FDA approved myChoice CDx companion diagnostic test. Illumina will develop a new HRD CDx test for the EU and the UK to aid in the identification of ovarian cancer patients with positive HRD status who are eligible for treatment with LYNPARZA (olaparib), a first-in-class PARP inhibitor, jointly developed and commercialised by Merck and AstraZeneca.
“With such great advances in precision medicine being made by companies such as Merck, it’s essential that patients who would benefit from LYNPARZA are identified,” said Joydeep Goswami, Chief Strategy and Corporate Development Officer of Illumina. “By leveraging our comprehensive genomic profiling family of products, TruSight Oncology, and the gold standard myChoice HRD technology, Illumina aims to offer the best-in-class HRD assay that is broadly accessible. By harnessing the incredible medicines development expertise of Merck, together we will be able to leverage the use of precision medicines to make a real difference for patients.”
“HRD testing should be an essential component of clinical diagnosis as half of all newly diagnosed patients with advanced ovarian cancer have HRD-positive tumors,” said Dr Eric Rubin, Senior Vice President, Early-Stage Development, Clinical Oncology, Merck Research Laboratories. “Biomarker testing has rapidly enhanced our understanding of how PARP inhibition can help target a devastating disease, like ovarian cancer and we are excited to partner with Illumina on the development of a distributed CDx HRD assay for the EU and UK.”
Image credit: National Cancer Institute