Guide: How to build an effective protein degrader

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NanoTemper outlines four questions to ask yourself to ensure you’re on the right track

Working in PROTACs, you’re tasked with the most challenging targets — that aim to address intractable diseases such as cancer, Alzheimer’s, or Parkinson’s disease. Despite the impressive promise of PROTACs, you still have to overcome many hurdles in order to work with these difficult targets.

This guide from NanoTemper highlights the four major stages of targeted protein degradation, the challenges at each step, and questions you should ask yourself to make sure your final product will result in a complete protein degradation.

Download this guide to learn:

  • What are the most common roadblocks at key stages in PROTAC development
  • What methods and technologies help you overcome these challenges
  • What outcomes you should expect at each stage



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