If you are a biotech scientist interested in reversing or overcoming the state of T-cell exhaustion, this webinar will be of interest.
Quantifying T cell exhaustion: An insight into BiTE antibodies and CAR-T cells for improved therapeutics will be hosted by DDW and presented by Sartorius. It will examine T cell exhaustion and how it is recognised as a major challenge in the development of immuno-oncology therapies.
T cells are fundamental in the coordination and execution of immune cell-mediated killing of infected or cancerous cells. Throughout the development of a T cell, variations in surface marker expression and cytokine release lead to important changes in function. Following antigen recognition, cytotoxic effector T cells become activated, inducing target-cell killing capabilities. Repeated stimulation can lead to loss of function due to T cell exhaustion and ultimately cell death. Post antigen clearance, some effector T cells will transition into long-term memory T cells which retain survival and proliferation properties. These provide lasting immunity through their ability to rapidly expand when re-exposed to a specific antigen.
Lauren Kelsey, a scientist in the iQue applications group, part of the European based BioAnalytics at Sartorius will discuss how the development of tumour-specific immunotherapies focuses on overcoming this exhausted phenotype of T cells to allow targeted killing of the tumour.
A growing number of immunotherapies, for example bispecific antibodies, checkpoint inhibitors and CAR-T cells, are being developed, targeting various stages in T cell activation and differentiation pathways. The goal of these therapeutics is to enhance the natural power of the immune system to eliminate diseases such as cancer. Detailed characterisation during the course of T cell development has the potential to offer greater insights leading to improved therapeutics.
Kelsey has been involved in the research and development of novel applications at Sartorius. She will examine the use of advanced flow cytometry to quantify T cell exhaustion phenotypes and cytokine release; how Bispecific T cell Engager (BiTE) antibodies in an immune cell killing assay affect T cell exhaustion and the influence of target cells on CAR-T cell exhaustion.
To listen to this free-to-attend webinar, which will take place on 22 October 2020 3:00 PM – 4:00 PM BST please sign up here (subject to approval).
Date: 22 October 2020
Time: 3pm UK BST
Duration: 1 hour
Cost: Free-to-attend (participation subject to approval)
Click here to register for free