Humanization of highly immunodeficient NSG mice with hematopoietic stem cells or peripheral blood mononuclear cells provides a powerful platform for very precise modeling of human immune responses. These immune-humanized platforms enable researchers to test a wide range of human-specific therapeutic approaches developed to either up or down regulate immune function.
Join DDW for this exclusive free event, Comparing immune-humanized platforms: Which one is best for my application? which is supported by The Jackson Laboratory.
Expert Brian W Soper, PhD, Senior Scientific Engagement Manager, The Jackson Laboratory will explore differences in immune engraftment based on the cells implanted and the host used to support those cell populations. Understanding these differences will empower you to choose the most appropriate platform(s) for your scientific endeavour.
The event will take place on July 6 at 3PM BST.
What you will learn:
- The differences in human immune cell reconstitution following engraftment with HSC or PBMC
- How genetic modification of the host influences hematopoietic humanization
- About the introduction of two new host platforms that improve human innate immune development