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        blood

        Patient using blood pressure monitor

        Positive Phase I results for RNAi therapeutic in hypertension

        25 July 2023

        Alnylam Pharmaceuticals has revealed results from its Phase I study of zilebesiran, an investigational RNAi therapeutic targeting liver-expressed angiotensinogen (AGT) in development for the treatment of hypertension. The results are published in the New England Journal of Medicine (NEJM). The key data showed that compared to placebo, zilebesiran was associated with dose-dependent reductions in serum […]

        Blood cells

        Promising new drug for chronic blood clotting disorder

        28 June 2023

        Takeda has revealed favourable interim results from its Phase III crossover trial evaluating the safety and efficacy of TAK-755 (recombinant ADAMTS13) replacement therapy for the prophylactic treatment of congenital thrombotic thrombocytopenic purpura (cTTP). cTTP is an ultra-rare, chronic and debilitating blood clotting disorder caused by a deficiency in ADAMTS13 enzyme. Clinical presentation of cTTP lies […]

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