3D modelling

AI drug discovery company Optibrium has acquired 3D drug design specialist BioPharmics. BioPharmics’ CEO, Dr Ajay Jain, and Director of Applied Science, Dr Ann Cleves, will join the Optibrium team, respectively focusing on R&D and Application Science in the newly-created BioPharmics Division. BioPharmics has developed a series of algorithms and software for 3D ligand-based and […]

This is the latest episode of the free DDW podcast, “Mass spectrometry and CRISPR are pillars of drug discovery”. It covers two articles written for Volume 23, Issue 1 – Winter 2021/22 of DDW. They are called “How ASMS offers more than seeing what sticks” and “CRISPR screening in the third dimension”. In the first […]

Culturing cells in 3D is simply a more realistic way to model how cells move and function in vitro. Spheroids, organoids, and more complex 3D systems have been invaluable to research, drug discovery, and personalised medicine. This e-book, sponsored by Corning, offers a practical guide for demystifying spheroids and organoids together with helpful tips for successfully […]

CELLINK, A BICO company, has launched BIO CELLX, a novel system that automates 3D cell culture workflows by leveraging pre-validated protocols.   The platform  The BIO CELLX builds upon CELLINK’s bioprinting portfolio which utilises technologies. By introducing the concept of pre-validated protocols, the platform provides cell biologists a solution for the development of 3D models […]

PerkinElmer Informatics has announced version 21 of its ChemDraw software, which provides researchers with the ability to import, animate and share 3D chemical structures natively in the Microsoft PowerPoint application.   Impact  The key enhancement helps chemists create more intelligent research reports quickly and easily, improving information sharing and collaboration and supporting real-time decision making.  Using […]

Listen to this article on the DDW Podcast: Rosie Bryan & Carlos le Sage, Horizon Discovery, explain how CRISPR-Cas9 technology has become a gold standard for functional genomics.  While efforts in the cancer genomics field have uncovered the mutational landscapes in tumours covering many types of cancer, the functional contribution of the mutated genes to cancer onset and […]

NovAliX, a CRO specialising in drug research and development, has partnered with Sanofi for the development of new DNA-Encoded Libraries (DELs), allowing the partners to design both general and focused chemical libraries, and carry out screening activities to identify new and useful chemical structures.  Why is this useful?  DEL technology can be used to support the drug […]

PerkinElmer has launched Signals Image Artist software, an image analysis and management platform for drug discovery research. The new offering is designed to help scientists accurately process and analyse their high-content screening (HCS) and cellular imaging data in a matter of hours, versus days or weeks, so they can make more informed decisions faster. The Signals Image Artist offering […]

More physiologically and pathologically relevant preclinical human liver models are needed for drug liver liability assessment and liver disease modeling. While Drug-Induced Liver Injury (DILI) remains a major safety concern, several recent high-profile NAFLD/NASH clinical trial failures further highlight this critically unmet need. With the advances in 3D culture, we and others have demonstrated the […]

More physiologically and pathologically relevant preclinical human liver models are needed for drug liver liability assessment and liver disease modeling. This app note offers insight and media for drug discovery.  While Drug-Induced Liver Injury (DILI) remains a major safety concern, several recent high-profile NAFLD/NASH clinical trial failures further highlight this critically unmet need. With the advances […]

Anti-androgen therapy is commonly used to treat patients with advanced prostate cancer which has spread to the bones, however, the treatment may be fuelling bone cancer spread.  Dr Nathalie Bock from QUT Centre for Biomedical Technologies focused her research on bone metastases from breast and prostate cancers. The research team investigated its hypothesis that traditional anti-androgen therapy […]

Lonza and CN Bio have entered into a distribution agreement where Lonza will supply a selection of hepatic cells to be prequalified by CN Bio for use in its PhysioMimix Single-and Multi-Organ MPS. The aim is to change the way human-relevant pre-clinical data is generated. With prequalified cells, customers can avoid having to trial numerous […]

King’s College London is using CNBio’s PhysioMimix Multi-Organ MPS. Following a research collaboration, King’s College London selected the system to create a human-relevant liver-intestinal model for characterising and manipulating host-microbial interactions, to support improved outcomes in cirrhosis. Launched in March 20211, the product combines CN Bio’s in vitro 3D liver model with a range of […]

The HepGo Assay-ready 3D Liver Spheroid Kit leverages Corning Life Science’s 3D cell culture technology in liver biology and ADME/Tox. Corning has developed an all-in-one solution for the development of 3D liver models that has been designed to better recapitulate in vivo behaviour. The kit is said to deliver a more physiologically relevant model over […]

The first outcome of the Optibrium and BioPharmics collaboration will be a new module for StarDrop, Optibrium’s small molecule design, optimisation and analysis software,. The new Surflex eSim 3D module, planned for the third quarter of 2021, will leverage BioPharmics’ three-dimensional (3D) ligand-based design approaches, offering exceptional virtual screening and compound design capabilities for targets […]

Lu Rahman takes look at some of the latest imaging innovation available and how it can benefit drug target identification and drug discovery research. Imaging is an important element within the drug discovery and development process providing researchers with information that can help identify potential drug targets or see how drugs are working. Developments in […]