Flow cytometry in immuno-oncology: tools to evaluate potential drugs

Researchers are continually looking for processes and technology that give them the edge scientifically or commercially.

If you are a biotech scientist interested in reversing or overcoming the state of T-cell exhaustion, this webinar will be beneficial to your work. Quantifying T cell exhaustion: An insight into BiTE antibodies and CAR-T cells for improved therapeutics will be hosted by DDW and presented by Sartorius. It will examine T cell exhaustion and how it is recognised as a major challenge in the development of immuno-oncology therapies.

This webinar will allow researchers to gain a better understanding of how advanced flow cytometry can be used to effectively evaluate immuno-oncology drugs using physiologically relevant assays. Being able to predict how drugs will work in vivo is an important factor in their development and this webinar will show how in vitro assays can be used to do this. The end-to end solution for therapeutic drug interrogation outlined in this talk provides a significant advantage to the user by creating an environment for fast, accurate decision making, thus speeding up the drug discovery process.

Immuno-oncology is growing in significance in cancer treatment. This webinar recognises the importance of this area of medical science and the developments that researchers are investigating. Exhaustion occurs when T cells are subject to chronic antigen exposure. This phenomena commonly occurs within the tumour microenvironment causing T cells to suffer a loss of their cytotoxic function meaning they lose their ability to kill cancerous cells.

Developing therapeutics which reverse and/or block T cell exhaustion in vivo will be vital in allowing the host immune system to effectively attack the cancerous cells. These therapeutics can be used in combination with other drugs or genetically engineered cells to allow enhanced killing.

This webinar highlights how the iQue3 and the T cell exhaustion cell and cytokine kit can be used together to rapidly quantify both phenotype and function. It will focus on how T cells from either a mono- or co-culture study can be used to identify and quantify exhausted phenotypes over time. Providing insight into the timeline of marker expression, effect of activation types on T cell exhaustion and target cell number quantification.

The event will be delivered by Lauren Kelsey, a scientist in the iQue applications group, part of the European based BioAnalytics at Sartorius. She has been involved in the research and development of novel applications at Sartorius and will examine the use of advanced flow cytometry to quantify T cell exhaustion phenotypes and cytokine release; how Bispecific T cell Engager (BiTE) antibodies in an immune cell killing assay affect T cell exhaustion and the influence of target cells on CAR-T cell exhaustion

To listen to this free-to-attend webinar, which will take place on 22 October 2020 3:00 PM – 4:00 PM BST please sign up here (subject to approval).

Webinar overview

Date: 22 October 2020
Time: 3pm UK BST

Duration:  1 hour
Cost: Free-to-attend (participation subject to approval)

Click here to register for free.






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