Therapeutics
This section features DDW articles around therapeutics
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Perspective on Systems Pharmacology: When multi-targeting is advantageous By Dr Kirkwood A. Pritchard Jr, Dr Dustin P. Martin and Dr Stephen Naylor Winter 2018/19
The safety and efficacy of therapeutic drugs still requires improvement. In part this is due to the promiscuity of individual drugs, which on average can interact with an estimated 6-28 other off-target moieties.

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The Evolution of Transdermal Drug Delivery and Treating Migraine By Dr Mahmoud Ameri and Hayley Lewis Winter 2018/19
Oral drug delivery is the most common and convenient route of drug administration due to a high rate of patient compliance, cost-effectiveness, portability, ease of production and pre-determined dosage.

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Current Trends in RNA-based Therapeutic Development By Dr Xiaoqiu Wu and Dr Andrew P. Turnbull Fall 2018
Cellular RNAs play crucial roles during disease progression and represent a diverse and largely untapped class of biomolecules that can be exploited for drug development.

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Therapeutics Discovery at MD Anderson - Making Patients a Priority During Drug Development By Dr Phil Jones Fall 2018
The mission at The University of Texas MD Anderson Cancer Center is to eradicate cancer, which remains a major cause of mortality worldwide. It is the second leading cause of death in the United States and globally, claiming more lives than malaria, HIV/AIDs and tuberculosis combined (or ~1 of every 7 deaths) (1-3).

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Hepatic Model Helps to Predict Clinically-Relevant Botanical-Drug Interactions By Dr Amy L. Roe and Dr Jonathan P. Jackson Fall 2018
Use of botanical-based dietary supplements is increasing among people of all ages and in most geographies. Most of these populations have ready access to conventional medications, with significant polypharmacy observed in older adults.

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Antibiotics & Antimicrobial Resistance (AMR) - A Global Perspective Professor Anthony Coates and Dr Yanmin Hu Summer 2018
Antibiotic resistance is at a crossroad. In the world today, deaths in low income countries from Antimicrobial Resistance (AMR) are predicted to rise dramatically by 2050.

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Analytical Biophysical Tools To Accelerate Discovery of Therapeutic Antibodies By Dr Yasmina Noubia Abdiche Summer 2018
The innate ability of antibodies to bind their targets with high affinity and exquisite specificity is leveraged in the discovery of therapeutic antibodies to treat a broad range of diseases including cancer, autoimmune disease and heart disease.

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Cell Therapy - Preserving Cell Integrity and Viability To Drive Discovery Mary Kay Bates Summer 2018
Cell therapy is poised to play a pivotal role in the development of precision and personalised medicines that will transform healthcare for millions of patients worldwide.

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Bringing Immuno-Oncology Together: How An Immunologist & Oncologist Collaborate By Dr Julia Schuler and Dr Louise Brackenbury Spring 2018
For many years, immunology and oncology operated as separate disciplines within drug discovery. However, recent advances in immuno-oncology (IO) have demonstrated what can be achieved when the two disciplines join forces in developing novel treatments for patients.

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Treating Cancer - How Natural Killer Cell Therapy (NK Cell Therapy) Will Transform Immunotherapy By Dr Azusa Tanaka and Dr Michael Seiler Spring 2018
Regulatory approval of CAR-T cell therapies in 2017 placed the spotlight on immunotherapy approaches that use live cells to attack tumours – a major shift in oncology treatment and the battle against cancer.

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Therapeutic Antibodies - New tools to enhance the antibody drug pipeline By Dr Robert Ford & Dr Toni Hoffmann Winter 2017/18
Therapeutic antibodies are the fastest growing class of drugs, with continuous increases in the number of innovator and biosimilar drugs in development.

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Nanomedicines - Exploring The Past, Present and Future By Professor Yvonne Perrie & Dr Euan Ramsay Fall 2017
Nanoparticles, and liposomes in particular, are growing in popularity as drug delivery vehicles for anti-cancer agents and inflammatory disease therapies, as well as forming the basis of a new class of vaccines.

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Oral Peptide Therapeutics - A Holy Grail or Quixotic Quest? By Dr Paul Shields Fall 2017
Technologies have been honed to overcome many of the challenges of administering peptide therapeutics orally, but obstacles remain before drug developers can fully realise the vast potential.

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Tackling Multi-Drug Resistant Bacteria By Dr Ankit Mahadevia Summer 2017
Antibiotic resistance never should have become the public health crisis we are seeing today. As a society, we thought the problem of bacterial infections had been solved decades ago when more than 200 powerful antibiotics representing different classes such as beta-lactam, tetracyclines and macrolides were developed.

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Raising The Bar On The Biologics Potential Dr Michael Mouradian Summer 2017
In the quest for safe, efficacious and profitable therapies, pharma research is changing. There is continued pressure to fill the drug pipeline and, at the same time, globalisation of personalised medicines is complex, expensive and requires a significant time commitment.

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The Rise of Immunotherapies - Strategies to Accelerate Their Advance Into Clinical Trials By Edward Cribb Summer 2017
The striking rise of immunotherapies in the past decade has had a transformative effect on the prospects for the treatment of patients with cancer.

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Therapeutics
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