Stem cells

Protein Arrays for Assessment of Target Selectivity By Professor Ian Humphery-Smith, Dr Erik Wischerhoff and Dr Ryuji Hashimoto Transforming knowledge of the human genome into a lead optimisation tool. Genomics activity has been criticised for having elucidated a plethora of potentially interesting drug targets, each awaiting further validation, but having not yet revolutionised the pharmaceutical […]

Share Share Tweet Email Stem Cell PHARMACEUTICS Stem Cell PHARMACEUTICS By Dr Gregory G. Lennon Recent research advances in the understanding of stem cell properties are inevitably leading to therapeutic strategies potentially applicable to many diseases. The pharmaceutical manipulation of multipotential cells such as stem cells is therefore now primed to evolve in its own […]

Predictive chemoinformatics applications to the pharmaceutical industry By Dr Leslie J. Browne and Laurie L.Taylor While significant advances in chemoinformatics present tremendous opportunities to improve human health, the future of chemoinformatics in the pharmaceutical industry is not without significant challenges. Chemoinformatics is the result of collective advances in chemistry, biology, computer sciences and statistics and […]

Proteomatics – New information resources for proteomics By Dr David J Parry-Smith and Dr David S Bailey Proteomics is the science of understanding protein architectures at a supramolecular level, whereas the realm of understanding the organisation of biological information in its totality belongs to bioinformatics. Somewhat more prosaically, industrial bioinformatics is about data handling and […]

The emergence of pharmacogenomics within the pharmaceutical industry By Aidan Power, Suzin Webb, Dr Albert Seymour and Dr Patrice Milos The sequencing of the human genome represents one of the most significant scientific advances of the 20th century that will shape the foundation of medical research well into the 21st. This accomplishment was enabled by […]

The Once and Future Microarray Market By Dr Ken Rubenstein Although the future for micorarray technology looks bright, the DNA microarray consumer is faced with a number of important choices regarding sources and technologies. Developers, users, and afficionados of DNA microarray technology, who happened on July 25, 2002 to peruse the day’s crop of press […]

The importance of using human-based models in gene and drug discovery By Dr Michael G. Palfreyman, Dr Vinod Charles and Jeffrey Blander Completion of the human genome sequence has opened an unprecedented opportunity to discover the genetic contribution to many of the complex diseases that afflict humans and to use this information for new approaches […]

Drug development for skin diseases based on functional genomics By Dr Jorn-Peter Halle With the high number of sufferers from skin disease around the world, it is astonishing that there are relatively few treatments available and that many of these only serve to relieve symptoms. Can drug development based on a functional genomics approach be […]

Fine-tuning the technology strategies for lead finding By Sandra Fox, Dr Shauna Farr-Jones, Dr Lynne Sopchak and Dr Helen Wang HTS has become the workhorse of pharmaceutical and biotechnology companies’ drug discovery efforts, with expanding responsibilities and increasing pressures to screen more targets with better compound libraries to find high-quality leads. HTS groups have taken […]

Monoclonal Antibodies – Magic bullets or a shot in the dark By Dr Fiona Adair It has been 16 years since the first monoclonal antibody was approved for therapy in acute transplant rejection. Now, with a further nine therapeutic monoclonal antibodies approved for use and some 16 in phase III trials or beyond, are we […]