Medicinal chemistry

High-throughput Crystallisation By Dr Sara Moran and Dr Lance Stewart With structure-based drug design on the increase can the development of high-throughput crystallisation fulfil its promise to revolutionise the drug discovery process? In an era when the development of drugs is hindered by the exorbitant costs of discovery and clinical trials, any method that can […]

By Dr David C. U’Prichard It is almost axiomatic that the pharmaceutical R&D industry has not achieved in the last decade an increase in productivity (measured as high value NCEs) commensurate with the explosion of new biological information, chemistry techniques and information storage/retrieval/examination systems, let alone the real increase in industry R&D expenditure. In particular, […]

By Peter Ertl, Wolfgang Miltz, Bernhard Rohde and Paul Selzer Readily accessible tools with easy to use interfaces, especially integrated into regularly used desktop applications, can improve the impact of cheminformatics in pharmacological research. Starting either from a single molecule or from a larger data set, these tools provide information that can considerably improve the […]

Recent Developments in Combinatorial Chemistry By Dr Anthony D Baxter Combinatorial chemistry has advanced significantly from the early 1990s when it was a new science of mainly conceptual interest to today where it has evolved into a key component of the drug discovery industry. The needs of the Pharma industry have demanded that compound libraries […]

Plants as a source of new medicines By Jennie Gwynn and Peter J Hylands Putting aside the excitement surrounding the human genome, in the near future we may well start to see the emergence of a new class of prescription medicine containing complex mixtures of plant extracts. This article discusses the important role that plants […]