Highlights from GlobalData’s CRO Benchmark Report By Adam M. Dion The biopharmaceutical industry is currently facing significant headwinds. The blockbuster era is over, development costs are skyrocketing, uncertainty exists around regulatory and reimbursement, patent cliffs, generic erosion and a sluggish global economy all have industry executives losing… Read More
Outsourced Kinase Profiling Services: Adding Value To In-House Kinase Programmes Dr John Comley Biochemical kinase profiling using a large panel of kinases with a broad coverage of the human kinome has become the de facto norm within the Pharma industry. The importance of this activity is demonstrated… Read More
Unrevealing Biological Secrets By Single Cell Expression Profiling By Dr Mikael Kubista and Dr Anders Ståhlberg During the last 30 years exceedingly sensitive and accurate technologies have been developed to measure and quantify amounts of nucleic acids and proteins. With techniques such as… Read More
A Decade of RNAi Screening: Too much hay and very few needles By Bhavneet Bhinder and Dr Hakim Djaballah RNAi screening is arguably the fastest growing field with the premise to better understand gene function at the genome level. It has been hailed as the second genomics… Read More
Stem Cells Rapidly Gaining Traction in Research and Drug Discovery By Dr John Comley A recent market survey on stem cells in research and drug discovery showed that despite a significant amount of hype and hope around stem cells, most drug discovery-related efforts today still fall into the… Read More
Are Laboratories Truly Ready For Mobile Working? By Sarah Westall It is not too long ago that mobile technology was limited to a certain few, but these days devices such as smartphones and tablets play an important part in many people’s working and personal lives. Read More
Laboratory Automation Advances High Throughput Bio-Inspired Research Into Personalised Medicine By Dr Joshua LaBaer The Biodesign Institute at Arizona State University plays an important role in addressing global healthcare challenges by developing bio-inspired solutions that can be translated into commercially viable products and clinical practices. Read More
Academic Ingenuity and Corporate Partnerships: New models in human health ventures bring value to all By Professor Paul Agris Many disapprove of science faculty at American universities procuring corporate ventures that support research, instead of primarily functioning as an instructor, mentor and basic researcher. This perception is… Read More
Multi-Parameter Flow Cytometry Technology Advances for Rare Cell Analysis and Sorting By David Gebhard and Dr Diether Recktenwald The study of rare cell populations is important to advance medical diagnostics and therapeutics. For many clinical studies, rare cell counts promise to provide valuable alternate end points; examples… Read More
There are approximately 7,000 rare diseases, which from a regulatory perspective are defined as those diseases where there are less than 200,000 patients in the US or that affect no more than five in 10,000 of the general population in the EU. Read More
Realising The Genome’s Potential In The Context Of The Living Cell By Dr Amr Abid A decade ago, with the completion of the Human Genome Project (HGP), scientists had the long-awaited sequence of the human genome in hand. Once decoded, this invaluable source of data was anticipated to… Read More
Adoption Of High Content Screening At High Throughput Screening Laboratories By William Downey and Dr Jennifer Hartigan Over the past five years, a majority of HTS laboratories have adopted high content screening (HCS) in their operations. As HTS laboratories have sought more biologically-relevant assays, cell-based assays and high… Read More
An Automated Approach To Solving Pharma’s Cardiac Toxicity Conundrum By Dr Walter Westerink, Dr Nuria Piñeiro Costas, and Beppy van de Waart The pharmaceutical industry is facing ever-growing difficulties in developing new drugs and bringing them to market (1,2). Many factors stand in the way of R&D… Read More
Chemical Space, High Throughput Screening and The World Of Blockbuster Drugs By Dr Hakim Djaballah We are constantly told that if a high throughput screen does not identify hit(s) then blame it on the compounds in your library. The community has accepted this notion and unleashed a… Read More
By Dr John Comley The majority of life sciences labs are facing an unprecedented decline in capex budgets and their subsequent ability to purchase new laboratory instruments. The default option underpinning lab instrument and equipment sales to life sciences has historically been the outright purchase… Read More
DNA Sequencing: Latest Developments In Next-Generation Sequencing By Andrew Szopa-Comley Next-generation sequencing has expanded the frontiers of genomic research, opening up new avenues of enquiry and offering insights into diverse areas of biology. Rapid developments in this field are dramatically lowering costs and increasing speeds. … Read More
