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RNA interference a technology platform for target validation, drug discovery and therapeutic development. Summer 03

In the post genomic era, elucidation of the physiological function of genes has become a major rate-limiting step in the quest to develop 'gene-based-drugs'. As we advance in the 'functional omics' arena with a hope to discover novel drug targets and therapies, their validation is a pivotal step before clinical practice. Such an endeavour can be tested using small interference RNAs (siRNAs) or RNA-mediated genetic interference (RNAi).