RESULTS FOR : 'Lead optimisation'
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When Two Are Not Enough: Lead Optimisation Beyond Matched Pairs

Lead optimisation projects progress by making successive enhancements to one or more starting structures. This is a classic multi-objective optimisation procedure where the goal is not only to improve potency but also to improve physicochemical and ADME properties.

Lead Generation and Lead Optimisation: the value of linking HT co-structure analysis and HT chemistry

The coupling of High Throughput co-structure analysis with focused library generation is not only proving a powerful general tool in lead optimisation but also increasing the probability of successful discovery of high quality oral development compounds for targets that have been quite difficult for the pharmaceutical industry.