RESULTS FOR : 'Kinase'
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Kinase Inhibitor Screening - Latest technologies and techniques

Kinases have become a proven target class for new drugs and have created a thirst for the development of new technology platforms for inhibitor detection. We discuss some of the latest technologies and techniques along with their advantages and disadvantages.

Kinases - Shedding Light on Kinase Drug Discovery

This article discusses the application of new assay technologies to shed light on kinase drug discovery.

Kinases and Drug Discovery: Protein Kinases as a Validated Drug Target

The role of protein and lipid kinases in cellular physiology and normal and abnormal growth has been well appreciated and has been the focus of intensive research in both academic arenas and pharmaceutical industries. The payoff for the pharmaceutical industries has been substantial.

Outsourced Kinase Profiling Services: Adding Value To In-House Kinase Programmes

Biochemical kinase profiling using a large panel of kinases with a broad coverage of the human kinome has become the de facto norm within the Pharma industry. The importance of this activity is demonstrated by the large number of service providers offering outsourced kinase profiling services.

Using RNAi to identify and validate novel drug targets: targeting human kinases with an siRNA library

Libraries of siRNAs directed against predefined subsets of genes now offer the capacity to greatly accelerate and improve the quality of functional genomics based drug discovery by enabling a much more targeted approach that effectively integrates the discovery and validation of novel targets.

Expanding the profile of Kinase Panels

With little sign of a decline in Pharma interest in kinase targets, greater emphasis is now being directed towards kinase selectivity profiling. A recent industry market survey suggests that although the market for kinase primary screening reagents is estimated to grow at an annual rate of 15%, that for outsourced kinase profiling is expected to reach 49% by 2005.

Kinase Screening and Profiling Products - Spoilt for choice

The end user is spoilt for choice with the range of alternative offerings, methodologies and approaches currently available for kinase screening and profiling.