RESULTS FOR : 'High content screening'
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Phenotypic Drug Discovery With High Content Screening

Early drug discovery used to be conducted mainly in a target-agnostic fashion, focusing on qualitative readouts from a living system - cells, tissue, or organisms - and asking the question, did this entity affect the phenotype?

Latest Developments in High Content Screening Systems

High-content screening (HCS) is a well-established approach for the multiparametric analysis of cellular events. Since its first introduction more than a decade ago, high content imaging systems have continually evolved with many improvements enabled to meet user demands of greater flexibility and the growing requirements of assays involving complex cellular disease models.

Adoption Of High Content Screening At High Throughput Screening Laboratories

Over the past five years, a majority of HTS laboratories have adopted high content screening (HCS) in their operations. As HTS laboratories have sought more biologically-relevant assays, cell-based assays and high content screening technologies have become more widespread.

New Tools Increase Accessibility to High Content Screening Assays

There have been major improvements in the instrument offerings and tools that enable high content screening (HCS) over the past decade.

When High Content Screening Meets High Throughput

The terms High Content Imaging (HCI) and High Throughput Screening (HTS) were introduced more than a decade ago (1) and are defining the use of automated microscopy and automated image analysis in the context of drug discovery.

High Content Screening - Emerging importance of novel reagents/probes and pathway analysis

The number of high content screens will increase by 50% over the coming year; signal pathway analysis was seen as the most relevant high content screening (HCS) application; with greatest interest in applying HCS coming from oncology groups.

High Throughput Screening, High Content Screening, Primary and Stem Cells

Over the past decade, the use of cell-based assays has accelerated in modern drug discovery. Indeed, the majority of assays in either target validation or lead identification/optimisation all now employ cell-based technologies.

High Content Screening - The next challenge: effective data mining and exploration

The use of high content screening within HTS is growing and with many past hurdles now overcome, the need for effective tools for data analysis is becoming paramount.