RESULTS FOR : 'Cell culture'
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3D Organoid Cell Culture - Optimising disease models for research and drug discovery

The use of human-induced pluripotent stem cells (HiPSCs) continues to grow in three-dimensional (3D) spheroid and organoid culture.

3D Cell Culture - Engineering Composable, Disease-Tunable 3D Human Microtissues for Drug Discovery

In this article, we will share some of what we have learned over the past 10 years as pioneers in the 3D cell culture space and provide guidance for those who are just getting started with 3D models and end-point assays.

Increasing Drug Discovery Success With 3D Cell Culture Systems

Drug candidates often fail in the clinic for two reasons: they lack efficacy or possess an adverse toxicity profile. These failures can come at a high cost, especially when drug candidates have already progressed along the development pipeline to clinical trial.

High-Throughput Spheroid Culture - Applications of 3D Cell Culture

In this article, we describe applications of high-throughput screening using 3D cell culture to assess cell viability. In addition, we highlight the importance of including multiple cell types in 3D assays to more accurately assess potency of chemotherapeutic drug candidates.

Spheroids Rapidly Becoming a Preferred 3D Cell Culture Format

There are many advantages associated with culturing cells in three-dimensional (3D) versus conventional two-dimensional (2D) tissue culture. Scaffold-free 3D cell culture systems that generate spheroids (and other similar multicellular aggregations) have proved useful as they offer an easy route to access 3D cell culture and transition into plate-based higher throughput.

3D Cell Culture - A Rapidly Emerging Technique for Drug Discovery

The past decades have witnessed significant efforts toward the development of three-dimensional (3D) cell cultures. Today, 3D cell cultures are emerging not only as a new tool in early drug discovery, but also as potential therapeutics to treat disease.

Ex Vivo vs In Vivo - The challenge of generating meaningful results with traditional cell culture

While the use of human cell lines has become a permanent fixture in drug discovery and development, the lingering issue has been in their inconsistent results.

Progress Made In Applying 3D Cell Culture Technologies

3D cell culture has the potential to deliver higher quality culture information that is more representative of tissue morphology and predictive of drug responses in vivo.

Automating cell culture to optimise cell line generation and selection

Cell culture is and has historically been an essential component of the drug discovery toolbox. Cell culture provides the proteins, membrane preparations and other raw materials required for biological research.

3D Cell Culture: Easier said than done

The transition from cell culture on the flat surface of a conventional two-dimensional (2D) culture vessel to a three-dimensional (3D) environment, matrix or scaffold with 3D architecture has begun, and is providing much needed support for emerging applications in tissue engineering and stem cell research.

3D Cell Culture Developments to Improve In Vitro Analyses

Improved in vitro models are required to aid the identification and assessment of candidate molecules for pharmaceutical development. Conventional cell culture models involve the growth of cells on two-dimensional (2D) substrates. Cells adapt to this synthetic 2D environment, become flattened and behave in an aberrant fashion.