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Analysis could find drug targets for attention deficits and sensory hypersensitivity

Many people with autism experience sensory hypersensitivity, attention deficits and sleep disruption. One brain region implicated is the thalamic reticular nucleus (TRN), which is believed to act as a gatekeeper for sensory information flowing to the cortex, by Anne Trafton, MIT News Office

New analytical platform accelerates analysis of trace elements for routine lab applications

Thermo Scientific iCAP PRO Series ICP-OES instruments capture a complete spectrum in a single measurement for high matrix samples.

Optimising Phenotypic Screening - Single-cell analysis versus 3D multicell analysis

In light of the high failure rate of compounds when they are subjected to clinical testing, we are seeing a renaissance in phenotypic screening in drug discovery. However, most phenotypic screening is based on the use of cellular assays and here we debate the advantages and disadvantages of single-cell versus 3D multi-cell analyses.

Integrated Platform Drug Discovery and Development Companies - Part 2: Comparative analysis

Large pharmaceutical companies have struggled to efficiently implement tools, technologies and platforms into their drug discovery and development (DDD) programmes.

Growing Market for High Content Analysis Tools

Two market surveys and a recent major scientific meeting have all highlighted the growing interest in High Content Screening (HCS) and point to the momentum which now surrounds the implementation of high content analysis tools.

Serial vs Direct Dilution - Time to apply new thinking to IC50 determination and dose-response analysis?

The serial dilution method is standard practice in the preparation of doseresponse series for IC50 determination. However, it is well recognised that inadequacies in the liquid handling or mixing technique will affect the dilution ratio and hence the compound concentration and any errors will be compounded during each successive serial dilution, mix and transfer.

Microfluidics - Driving Innovation and Streamlining Single Cell Analysis

Microfluidics platforms that harness picodroplet technology (picolitre volume aqueous droplets in stabilised oil emulsions) are unlocking the potential of single cell analysis to enable exciting new discoveries and advances with the potential to transform scientific research, drug development and precision medicine.

Therapeutic Drug Repurposing, Repositioning and Rescue Part IV: Financial model and analysis

There is a growing consensus that Drug Repurposing, Repositioning and Rescue (DRPx) impacts all stakeholders involved in the therapeutic drug sector.

New Developments in Single Cell Separation and Analysis Technologies

Recent advances of single cell technologies are facilitating the opportunity to discern biological insights within individual cells and providing a means to reveal previously hidden relationships between individual cells within a population.

Multi-Parameter Flow Cytometry Technology Advances for Rare Cell Analysis and Sorting

The study of rare cell populations is important to advance medical diagnostics and therapeutics. For many clinical studies, rare cell counts promise to provide valuable alternate end points; examples are circulating tumour cells in peripheral blood, tumour stem cells, endothelial cells in blood, hematopoietic progenitor cells and their subpopulations, antigen specific T-cells and foetal cells in maternal circulation.

Biological Analysis and Interpretation For Improved Research Outcomes

In the last few years, technological advancements in the life sciences have changed many ways in which we think about research. Next-generation sequencing, qPCR and microRNA offer new avenues to ask and answer research questions in more detail and in less time.

Pathway Analysis - Understanding the bridge between environmental cues and cellular response

Understanding the function of a protein in the context of normal and abnormal cellular processes requires a comprehensive knowledge not only of its regulation but also of its role in signalling and metabolic networks in the cell.

Optimising Well Results In Label-Free Analysis

Bearing in mind the cost and time required to conduct a screening campaign, it is of paramount importance that screening laboratory scientists process and analyse screen data as carefully and consistently as possible. This paper argues that data analysis software that is modular, process-based and supports visualisation and flexible result generation is essential.

Gene function via the analysis of multi-pro

Affinity proteomic methods can translate genomic data into validated targets for drug discovery. Baits such as tagged gene product or small molecules obtained from cell-based assays are used to purify interacting proteins.

Lead Generation and Lead Optimisation: the value of linking HT co-structure analysis and HT chemistry

The coupling of High Throughput co-structure analysis with focused library generation is not only proving a powerful general tool in lead optimisation but also increasing the probability of successful discovery of high quality oral development compounds for targets that have been quite difficult for the pharmaceutical industry.

Gene Expression: Analysis and Drug R&D

It is clear that gene expression profiling systems have a role to play in many facets of drug discovery and development, but several questions remain. We take a look at the use of DNA microarray for gene expression or expression profiling and how DNA chips are used for drug discovery and development as a whole.

High Content Screening - Emerging importance of novel reagents/probes and pathway analysis

The number of high content screens will increase by 50% over the coming year; signal pathway analysis was seen as the most relevant high content screening (HCS) application; with greatest interest in applying HCS coming from oncology groups.

Modular Automation for Screening: A cost/benefit analysis

Cost is now a key driver for pharmaceutical companies and in many respects shapes the capital, revenue and resource decisions that have to be made during the drug discovery process. Where companies are resource rich, the need for fully automated screening platforms is reduced and workstation-based systems tend to be more abundant.

Seeing is Believing: The Benefits of Visual Analysis in Research

There is a growing pressure in todays climate for pharmaceutical companies to find tomorrows wonder drugs and dominate the major market segments. Recently, they have also been under attack for poor research productivity, for failures in drug safety and for off-label marketing. The use of visual analysis could do much to improve their performance in research and across all areas of activity.

Progress in Systems-Based Analysis of Cellular Signalling

Drug discovery currently focuses on targeted approaches, relying on validation of the target as a disease driver. However, the underlying biological complexity of disease often frustrates these attempts at therapeutic intervention, resulting in high failure rates due to lack of efficacy.