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        Dementia

        Preclinical data supports new approach to Alzheimer’s disease

        17 August 2023

        Preclinical data has demonstrated that the oral small molecule OLX-07010 inhibits tau aggregation in a model for inherited tauopathies such as progressive supranuclear palsy (PSP) and frontotemporal dementia (FTD). Earlier…

        Antibody

        Novel antibody displays potent anti-inflammatory activity

        16 August 2023

        …potential clinical benefit for people with RA and IBD. The paper was authored by Dr Asif Iqbal from the University of Birmingham and Professor Francesco Maione, Head of ImmunoPharma Lab…

        Cancer cell

        Genetic biomarkers could personalise therapy for TNBC

        16 August 2023

        …to predict who will benefit from carboplatin and docetaxel using a range of different biomarkers and suggest further investigation of these biomarkers in clinical trials is warranted. The presence of…

        Medical researcher

        ADME and DDI considerations during drug development

        16 August 2023

        …your compound helps you avoid unnecessary clinical studies, costs, delays and more. This webinar will provide insights at a high-level related to regulatory drivers, investigatory objectives, and practical concerns for…

        Human neurone

        AI Parkinson’s discovery paves way for personalised treatments

        15 August 2023

        …likely to respond to a drug, before enrolling into clinical trials. The hope is that one day this could lead to fundamental changes in how we deliver personalised medicine.” Edited…

        Tumour microenvironment

        Immunotherapy for solid tumours progresses to human trials

        14 August 2023

        Research partners in the UK are progressing their orally available small molecule cancer immunotherapy drug into clinical development as a treatment for advanced solid tumours. Sosei Group and Cancer Research…

        This week in drug discovery (7-11 August)  

        11 August 2023

        …engager approved for UK clinical trial The UK MHRA has granted Aleta Biotherapeutics a clinical trial authorisation to evaluate biologic ALETA-001 in a Phase I/II clinical trial in patients with…

        Covid-19

        New antiviral potential solution to resistant Covid-19 variants

        10 August 2023

        In preclinical studies, a new pan-coronavirus papain-like protease (PLpro) inhibitor has shown a near complete reduction in SARS-CoV-2 viral load in the lungs. Infex Therapeutics has selected the clinical candidate…

        Medical research

        Learn about ADME and DDI considerations in drug discovery

        9 August 2023

        …your compound helps you avoid unnecessary clinical studies, costs, delays and more. This webinar will provide insights at a high-level related to regulatory drivers, investigatory objectives, and practical concerns for…

        Medical research

        Are in vitro metabolism and drug-drug interaction studies critical for an investigational new drug application?

        9 August 2023

        …risks of your compound helps you avoid unnecessary clinical studies, costs, delays and more. This webinar will provide insights at a high-level related to regulatory drivers, investigatory objectives, and practical…

        Child with respiratory syncytial virus

        ‘Compelling’ data for paediatric live attenuated RSV vaccine

        9 August 2023

        A new respiratory syncytial virus (RSV) vaccine candidate has achieved positive safety and immunogenicity results in a Phase I clinical study of RSV-naïve participants between the ages of six and…

        Ginkgo and Merck collaborate to improve biologic manufacturing 

        8 August 2023

        …are always seeking new and innovative ways to optimise process efficiency while maintaining product integrity,” said Dr Michael Kress, Senior Vice President, Development Sciences and Clinical Supply, Merck Research Laboratories….

        Heart monitor

        Research partners advance AAV gene therapy for heart disease

        7 August 2023

        …technology capabilities with Icahn Mount Sinai’s deep understanding of gene delivery and expertise in cardiovascular research and clinical translation. “This project is a significant step for Evox as it expands…

        Vaccine research

        UK vaccine centre offers opportunity for pandemic preparedness

        7 August 2023

        …could be improved, such as avian influenza, mpox (monkeypox) or hantavirus. VDEC’s teams are already running Phase I clinical trials for a potential world-first vaccine against Crimean-Congo haemorrhagic fever, a…

        This week in drug discovery (31 July – 4 August)  

        4 August 2023

        …of the ongoing Phase II clinical trial of PT-112 in patients with late-stage metastatic castration-resistant prostate cancer (mCRPC). Scientists create compound that can block cancer metastasis Researchers from the University…

        Bacteria

        Partners collaborate on new broad-spectrum antibiotic

        4 August 2023

        …able to accelerate the development of this promising antibiotic compound, by supporting clinical and pharmaceutical development activities, with the hope of getting it to patients where it is most needed.”…

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