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        Human heart model

        Miniature human heart has potential to reshape drug testing

        16 August 2023

        …pluripotent stem cells (hiPSCs), which are derived from adult, non-reproductive cells that have been genetically reprogrammed. “This is a new chapter in human physiology.” The tiny model has multiple chambers,…

        Antibody

        Novel antibody displays potent anti-inflammatory activity

        16 August 2023

        …increase the numbers of lymphocytes (white blood cells) in the blood. Further studies in mouse models of arthritis showed that therapeutic administration of Ab-IPL-IL-17 is as effective at halting disease…

        Human neurone

        AI Parkinson’s discovery paves way for personalised treatments

        15 August 2023

        A new study has demonstrated that machine learning can accurately predict subtypes of Parkinson’s disease using images of patient-derived stem cells, paving the way for personalised medicine and targeted drug…

        ""

        Whitepaper on digital PCR for lentiviral vector characterisation

        15 August 2023

        …Lentivirus Physical and Proviral DNA Titer Kits with the QuantStudio Absolute QDigital PCR System Measurement of lentiviral vector titers and provirus copies in transduced cells by digital PCR Long terminal…

        Illustration of a virus

        Next-generation antivirals could target virus membranes

        15 August 2023

        Researchers have shown that a group of novel molecules inspired by our own immune system inactivates viruses like Zika and chikungunya, and could help overcome antiviral resistance. “We found an…

        Tumour microenvironment

        Immunotherapy for solid tumours progresses to human trials

        14 August 2023

        …of prostaglandin receptor, the prostaglandin E2 (PGE2)-type prostanoid receptor 4 (EP4). In cancer, PGE2 acts in the tumour microenvironment to trigger cancer cells to evade the immune system. Targeting EP4…

        Warfarin

        Warfarin could be repurposed as a potent cancer drug

        11 August 2023

        A new study has shown that blood thinner warfarin could also treat cancer, as it stops tumours from interfering with a self-destruct mechanism that cells initiate when they detect mutations…

        Heart monitor

        Research partners advance AAV gene therapy for heart disease

        7 August 2023

        …a long-standing challenge in cardiovascular medicine, namely the safe and effective delivery of genetic medicines to cardiomyocytes. By enhancing the precision of gene delivery to heart muscle cells and evading…

        This week in drug discovery (31 July – 4 August)  

        4 August 2023

        …Medicine at Mount Sinai have designed an RNA-based strategy to activate dendritic cells that eradicated tumours and prevented their recurrence in mouse models of melanoma. Sarcoma ‘Rosetta stone’ could bring…

        Breast cancer cell

        PARP inhibitor use could be extended to more cancer patients

        2 August 2023

        …survive. Cancer cells unable to copy their DNA One of the ways PARP inhibitors work in cancer cells with changes in their BRCA genes is by preventing them from repairing…

        Microscopic image of brain organoids tissue

        Researchers create human brain organoids without animal cells

        2 August 2023

        …brain organoids are derived from embryonic or pluripotent stem cells and more closely model the complex brain structure compared to conventional two-dimensional cultures. Until now, the extracellular matrices in brain…

        Neuroblastoma

        Renaissance Pharma licenses Hu14.18 for neuroblastoma

        2 August 2023

        …chemotherapy, surgery, radiotherapy, stem cell transplantation and anti-GD2 mAb treatment. A novel Phase II trial incorporating Hu14.18 into induction therapy and additionally, within post-consolidation therapy, demonstrated outstanding patient outcomes with…

        T cells

        RNA-based immunotherapy eradicates melanoma tumours

        1 August 2023

        …types, were reported in Nature Nanotechnology. Cancer cells employ strategies to switch off various stages of the cancer-immunity cycle, the process by which dendritic cells educate T cells to kill…

        ""

        World Lung Cancer Day: Five drug discovery breakthroughs

        1 August 2023

        …demonstrated in a preclinical study a potential new therapeutic approach to non-small-cell lung cancer, which involves inhibiting the immune-system molecule TREM2 while enhancing natural killer cells. During tumour progression, the…

        Cancer cells

        Scientists create compound that can block cancer metastasis

        1 August 2023

        …systems of cells from the highly metastatic and incurable hormone receptor-free breast cancer. Using these model systems, researchers at the university’s Department of Biochemistry discovered a novel compound that can…

        Human eye

        First-of-its-kind gene therapy restores vision in DEB patient

        27 July 2023

        …treatment in the back part of the eye, but this new formulation targets the cells in the ocular surface. Sabater and Krystal Biotech are now working on a future clinical…

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