…pluripotent stem cells (hiPSCs), which are derived from adult, non-reproductive cells that have been genetically reprogrammed. “This is a new chapter in human physiology.” The tiny model has multiple chambers,…

…increase the numbers of lymphocytes (white blood cells) in the blood. Further studies in mouse models of arthritis showed that therapeutic administration of Ab-IPL-IL-17 is as effective at halting disease…

A new study has demonstrated that machine learning can accurately predict subtypes of Parkinson’s disease using images of patient-derived stem cells, paving the way for personalised medicine and targeted drug…

…Lentivirus Physical and Proviral DNA Titer Kits with the QuantStudio Absolute QDigital PCR System Measurement of lentiviral vector titers and provirus copies in transduced cells by digital PCR Long terminal…

Researchers have shown that a group of novel molecules inspired by our own immune system inactivates viruses like Zika and chikungunya, and could help overcome antiviral resistance. “We found an…

…of prostaglandin receptor, the prostaglandin E2 (PGE2)-type prostanoid receptor 4 (EP4). In cancer, PGE2 acts in the tumour microenvironment to trigger cancer cells to evade the immune system. Targeting EP4…

A new study has shown that blood thinner warfarin could also treat cancer, as it stops tumours from interfering with a self-destruct mechanism that cells initiate when they detect mutations…

…a long-standing challenge in cardiovascular medicine, namely the safe and effective delivery of genetic medicines to cardiomyocytes. By enhancing the precision of gene delivery to heart muscle cells and evading…

…Medicine at Mount Sinai have designed an RNA-based strategy to activate dendritic cells that eradicated tumours and prevented their recurrence in mouse models of melanoma. Sarcoma ‘Rosetta stone’ could bring…

…survive. Cancer cells unable to copy their DNA One of the ways PARP inhibitors work in cancer cells with changes in their BRCA genes is by preventing them from repairing…

…brain organoids are derived from embryonic or pluripotent stem cells and more closely model the complex brain structure compared to conventional two-dimensional cultures. Until now, the extracellular matrices in brain…

…chemotherapy, surgery, radiotherapy, stem cell transplantation and anti-GD2 mAb treatment. A novel Phase II trial incorporating Hu14.18 into induction therapy and additionally, within post-consolidation therapy, demonstrated outstanding patient outcomes with…

…types, were reported in Nature Nanotechnology. Cancer cells employ strategies to switch off various stages of the cancer-immunity cycle, the process by which dendritic cells educate T cells to kill…

…demonstrated in a preclinical study a potential new therapeutic approach to non-small-cell lung cancer, which involves inhibiting the immune-system molecule TREM2 while enhancing natural killer cells. During tumour progression, the…

…systems of cells from the highly metastatic and incurable hormone receptor-free breast cancer. Using these model systems, researchers at the university’s Department of Biochemistry discovered a novel compound that can…

…treatment in the back part of the eye, but this new formulation targets the cells in the ocular surface. Sabater and Krystal Biotech are now working on a future clinical…