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        CAR-T cell attacking cancer

        CAR-T cell therapy holds promise for ovarian cancer

        3 March 2023

        …Department of Oncology-Pathology at Karolinska Institutet. “Despite many improvements to the available therapy, the prognosis for women with ovarian cancer is still poor.” Until now, CAR-T cell therapy has proved…

        Blood in a Petri dish

        Haemophilia one-time gene therapy effective for three years

        13 January 2023

        …said Steven Pipe, Professor of Pediatrics and Pathology at the University of Michigan and an investigator in the study. “I am encouraged to see the consistent clinical response and the…

        ""

        Novel peptide targets early molecular trigger of Alzheimer’s

        14 December 2022

        …progress to mild cognitive impairment (follow-up was not available for one individual). These results suggest that the SOBA assay can detect early Alzheimer’s disease molecular pathology prior to clinical symptoms….

        CAR-T therapy

        CAR-T therapy successfully used to treat autoimmune disease

        6 December 2022

        …co-senior author Chyi-Song Hsieh, the Alan A and Edith L Wolff Professor of Rheumatology and a professor of medicine and of pathology & immunology. MS is marked by rogue T…

        Immunofluorescence

        New tool unlocks immunofluorescence data for drug discovery

        8 November 2022

        …compared to other solutions, while also reducing mIF analysis time-to-results from months to weeks. Dr Ken Bloom, Head of Pathology at Nucleai, said: “Our deep learning approach will enable the…

        Excitatory/inhibitory neuronal reporter

        Gene expression delivery tool ‘slides’ instructions into cells

        1 November 2022

        …in both preclinical and clinical models,” said Blackshaw. The current proof-of-principle study builds on previous research by Johns Hopkins Assistant Professor of Pathology, Jonathan Ling. He published ‘maps” depicting how…

        Dr Nevan Krogran receives Legion of Honour

        Covid-19 research group founder receives Legion of Honor 

        31 October 2022

        …award was given for forming an international research collaboration and for scientific contributions utilising a novel methodology of identifying the viral modifications of human proteins that fueled SARS-CoV-2 pathology to…

        Clinical study first step towards treating respiratory syncytial virus 

        18 October 2022

        …RSV clinical isolates in various cell types. In a mouse model of RSV infection, EDP-323 treatment was associated with dose-dependent decreases in viral load in the lung, reduced lung immunopathology…

        This week in drug discovery (3-7 October)

        7 October 2022

        …presence of amyloid pathology in the brain. Immune targets identified for chemo-resistant breast cancers Researchers from King’s College London and The Institute of Cancer Research, London, have performed a deep…

        Jigsaw puzzle of the brain

        New Alzheimer’s treatment reduces decline in Phase III trial

        6 October 2022

        A new Alzheimer’s disease (AD) treatment has been shown to reduce clinical decline in mild cognitive impairment (MCI) due to AD and mild AD with confirmed presence of amyloid pathology…

        Small cell lung cancer

        Combination therapy halts lung cancer tumour growth in mice

        5 September 2022

        …— platinum-based chemotherapy — and that adds maybe two to six months of life,” said co-senior author Nima Mosammaparast, MD, PhD, Associate Professor of Pathology & Immunology and of Medicine…

        Novel drug effective in a mouse model of Alzheimer’s disease

        13 April 2022

        …top of the spinal cord. A key feature is that they are the first to display a pathology early in neurodegeneration6. Neuro-Bio believes that detection and measurement of T14 could…

        C2i Genomics launches AI-powered cancer monitoring tests in Europe 

        13 April 2022

        …in countries accepting the CE Mark. The test provides a streamlined process for in-house use by any pathology lab and genomic cancer lab to offer testing closer to the patient….

        Are we getting a lead on Omicron subvariant? Study says yes 

        24 March 2022

        …in vitro neutralising activity assays in cultured cells. Official comments Michael Diamond, MD, PhD, The Herbert S. Gasser Professor, Departments of Medicine, Molecular Microbiology, Pathology & Immunology, Washington University, US,…

        FDA

        First live biotherapeutic approved to treat Parkinson’s disease 

        28 February 2022

        …disease pathology, including gut barrier integrity, neuroinflammation, oxidative stress and neuroprotection. In animal models of Parkinsonian syndrome, 4D pharma demonstrated that MRx0005 and MRx0029, respectively protected against the loss of…

        Study links gut fungi to inflammation in Crohn’s disease patients 

        11 January 2022

        …Cominelli, professor of medicine and pathology and associate dean for program development at the Case Western Reserve School of Medicine. “The next step in our research is to study other…

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