…activation. These new findings suggest that maintaining healthy mitochondrial function by blocking USP30 may slow or even stop the progression of pathology which drives PD. Professor Gabriel Balmus, Cambridge University,…

…treatments for these patients,” said Dr Van Gelder. “Based on shared pathology between RP and other inherited retinal diseases, we believe there is an opportunity to explore KIO-301 for several…

…from 54 subjects at the Glasgow Memory Clinic was shipped to PharmaKure for analysis. Key biomarker proteins associated with Alzheimer’s disease pathology are amyloid-β (Total, Aβ40 and Aβ42), α-synuclein and…

…fragment of reduced size, enabling an optimised penetration through all retinal layers to the most critical target site driving GA disease pathology. The companies believe that, based on its molecular…

…loss. This suggests that there may be human-specific factors at play in AD that standard mouse models can’t replicate. Understanding why mouse neurons are more resilient to amyloid pathology will…

…platform plays in realising the full value of data-driven drug discovery and development. He will walk through the three critical functions that Proscia’s enterprise pathology platform, Concentriq, performs in putting…

…insight and accelerating drug discovery with AI. He will walk through the three critical functions that Proscia’s enterprise pathology platform, Concentriq, performs in putting computational solutions into practice. What you…

…ones are protecting the host from the viruses. “These findings offer the first direct evidence that resident microbiota can have a significant impact on the establishment and pathology of infection…

…neurodegenerative diseases such as PSP and FTD. Since tau tangles and amyloid plaques are hallmarks of AD, treating both could be more beneficial to patients than targeting a single pathology….

…of Pathology & Cell Biology (in the Institute for Cancer Genetics) at Columbia University Vagelos College of Physicians and Surgeons. When the researchers performed genetic screens on human melanoma cells…

…by elucidating basic mechanisms of AD pathology and discovering imaging and blood biomarker tools to track the pathology,” said Dr Daniel Skovronsky, Lilly’s Chief Scientific and Medical Officer, and President…

…Activation Pathway), providing support for the presumed mode of action relating to modulation of activated (myofibroblastic) fibroblasts, as well as the ongoing clinical programmes. Pathology analysis Pathology analysis showed preliminary…

…electrical signals at the neuron-level across different brain regions can provide critical information in elucidating neural network function and the biological pathway behind neurological disease pathology. However, in vivo electrophysiology…

…“2023 Life Sciences Digital Pathology Adoption Survey” asked 40 senior executives from top pharmaceutical companies and leading contract research organisations (CROs) about their use of digital pathology, the benefits it…

…to prevent myelin degradation (demyelination), a hallmark pathology feature of MS and other neurogenerative diseases characterised by damage to the myelin sheath surrounding nerve fibres in the central nervous system….

A cloud-based digital pathology platform has helped a CRO deliver more informed preclinical studies. Proscia announced that Virscio, a provider of translational research and development services, has deployed Concentriq for…