Metrion Biosciences and LifeArc extend drug discovery collaboration

Metrion Biosciences, a specialist ion channel CRO and drug discovery company, and LifeArc, an independent medical research charity, have announced a 12-month extension of their neuroscience drug discovery collaboration, as a result of the continued success of their ongoing agreement.

The collaboration is focused on the discovery of novel selective small molecular modulators of a specific two-pore domain potassium ion channel target, identified as likely to be involved in neurological pathogenesis, and has now progressed into the hit-to-lead optimisation phase. Initially signed in January 2019, the collaboration agreement was extended for the first time in December 2019. Following the achievement of mutually agreed criteria LifeArc has now exercised the option to extend the programme for a further 12 months.

Under the terms of the agreement, Metrion provides validated ion channel and electrophysiology-based assays and safety profiling services. LifeArc uses its expertise to identify novel modulators of CNS ion channel targets and all new chemical syntheses, with Metrion evaluating the pharmacological activities of LifeArc compounds using both automated electrophysiology and manual patch clamp technologies

Dr Edward Stevens, Head of Drug Discovery, Metrion Biosciences, said: “The continued success of our collaboration with LifeArc is testament to the strength of both teams and the long standing and successful research relationship between our companies. The transition to lead optimisation for key chemical series, along with continuation of selected hit-to-lead activities, is very exciting, and I look forward to working together through 2021.”

Dr Justin Bryans, Executive Director, Drug Discovery, LifeArc, commented: “We are delighted to continue our work with Metrion in the field of neuroscience, capitalising on our combined expertise and capabilities to develop potentially life-changing drugs.”

Image credit: Scott Graham

Related Articles

Join FREE today and become a member
of Drug Discovery World

Membership includes:

  • Full access to the website including free and gated premium content in news, articles, business, regulatory, cancer research, intelligence and more.
  • Unlimited App access: current and archived digital issues of DDW magazine with search functionality, special in App only content and links to the latest industry news and information.
  • Weekly e-newsletter, a round-up of the most interesting and pertinent industry news and developments.
  • Whitepapers, eBooks and information from trusted third parties.
Join For Free