Informatics
This section features DDW articles around informatics in drug discovery.
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Ontologies - Semantic networks of pharmaceutical knowledge By Dr Stephen P. Gardner Summer 2005
In the current climate making information more transparent to internal R&D staff and to external audiences such as regulators and consumers is crucial to business effectiveness. A new generation of semantic technologies capable of generating a consistent view of knowledge derived from multiple diverse data sources is maturing rapidly.

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Redefining Drug Discovery Informatics By Bryan S. Koontz Summer 2005
As the pharmaceutical industry changes in response to unprecedented challenges, information technology supporting the drug discovery process must evolve and be redefined in order to improve research productivity and success rates.

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Unlocking the value in Data By Dr Amber Salzman Summer 2004
In recent years enormous sums have been spent on systems and data management, but are we getting full value from these investments? We discuss here how organisations, scientists and, indeed, vendors themselves must work as one to extract total value from our vast data repositories.

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The Current Bioinformatics Analytical Software Landscape By Charles Chang Summer 2004
With the vast amount of biochemical data generated from experiments conducted by research laboratories around the globe, there is strong demand for software to analyse and manage the data effectively.

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Tools for Target Identification, Validation and Biomarker Discovery By Dr Paul Denny-Gouldson Summer 2007
As automation in the drug discovery arena increases then so does the amount and complexity of the data. We discuss an emerging solution that now integrates various technologies to provide a scientific data intelligence tool giving scientists increasing scope to identify, evaluate and assess potential targets with reduced ‘lab-based’ experimentation.

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Enabling Collaborative Science via the Integration of Analytical Data into Organisational Systems By Mark Bayliss Summer 2007
The storage of data drawn from the analytical process has for years been the stumbling block in the overall ‘knowledge management’ of the discovery process.

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The evolving world of drug discovery data integration in the pharmaceutical industry Dr David Sedlock Spring 2007
The world of drug discovery has been impacted significantly by an ever evolving use of computer systems during the past 25 years with the greatest change occurring during the past 10 years or so as a consequence of the genesis of extremely large datasets from bioinformatics and cheminformatics operations.

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Collaborative eR&D By Richard ORourke Spring 2004
In 2001 at the GlaxoSmithKline inaugural shareholder meeting, Chief Executive JP Garnier was clearly not happy with what he regarded as the productivity crisis within the industrys R&D function.

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Making the Most of Drug Discovery Data By Dr Nick Davies and Dr Tim Peakman Spring 2004
Discovery scientists in most pharmaceutical companies are struggling with incompatible legacy systems, a growing volume of data and the imminent advent of a product model that will demand much more of them.

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Role of image informatics in accelerating drug discovery and development By Robert Dunkle Winter 2003
There is a new category of informatics that is proving itself essential to the acceleration of drug discovery and development. Image informatics is the systematic use of image data as a means to help interpret experiments and understand biology.

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In Silico Structure-based Drug Design - Shifting the bottleneck? By Dr Jonathan Heal Drug Discovery Spring 2003
The use of in silico methods in drug design has grown significantly in popularity over the past couple of years. Indeed many pharma companies have already adopted some type of virtual screening capability to complement HTS methods. Will we eventually see this technology replacing HTS and removing the burden of discovery chemistry?

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Predictive chemoinformatics applications to the pharmaceutical industry By Dr Leslie J. Browne and Laurie L.Taylor Fall 2002
While significant advances in chemoinformatics present tremendous opportunities to improve human health, the future of chemoinformatics in the pharmaceutical industry is not without significant challenges.

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Proteomatics - New information resources for proteomics By Dr David J Parry-Smith and Dr David S Bailey Fall 2002
Proteomics is the science of understanding protein architectures at a supramolecular level, whereas the realm of understanding the organisation of biological information in its totality belongs to bioinformatics.

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Implementation or algorithm? The value of Bioinformatics By Dr Christopher Hogue Spring 2001
Recently the value of bioinformatics has been questioned. The value can be proven but are there enough qualified and professionally trained people who know how to build good bioinformatics tools?

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Informatics
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