Enabling Technologies
This section features DDW articles around enabling technologies in drug discovery.
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How Advanced Automated Liquid Handling Systems are Reshaping Drug Discovery By Helen Stewart-Miller and Dr Richard Massey Winter 2018/19
Once the domain of high-throughput screening (HTS) applications, automated liquid handling systems are now used ubiquitously in drug discovery and have been fundamental in increasing throughput, driving efficiencies and improving standards of accuracy and reproducibility in pharmaceutical and biotechnology workflows.

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Microfluidics - Driving Innovation and Streamlining Single Cell Analysis By Dr Frank F. Craig
Microfluidics platforms that harness picodroplet technology (picolitre volume aqueous droplets in stabilised oil emulsions) are unlocking the potential of single cell analysis to enable exciting new discoveries and advances with the potential to transform scientific research, drug development and precision medicine.

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Technology Innovation Will Help Prepare Drug Discovery for Smart Screening Era By Dr Clive Green and Dr Philip Spencer
Drug discovery is undergoing a transformation powered by advances that magnitude more molecules and enable smarter selection of compounds.

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The Use of Next-Generation Sequencing in Drug Development By Keith Nangle & Mike Furness
This article summarises some of the technical and regulatory challenges posed by next-generation sequencing technologies and the efforts being made to address them.

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Collaborative Robots Are Redefining Lab Automation By Peter Harris
The use of robots to automate high-volume repetitive tasks has been common practice going back to the early 1970s, when the German company KUKA developed and deployed the first electromechanical industrial robot.

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New Approaches to Sample Identification Tracking and Technologies for Maintaining Stored Sample Quality By Dr John Comley
Safeguarding the quality of stored samples (both compounds and biospecimens) must be the driving ethos in compound management stores and biorepositories. Yet there are few innovations in available sample storage technologies that can help them easily identify poor sample quality or monitor sample degradation and so minimise erroneous downstream analytical results.

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Automated Liquid Handler Vendor vs Third Party Plastic Company by Dr John Comley
Competing for the disposable pipette tip business. Users of automated liquid handlers today invariably have a choice – obtain disposable pipette tips from the original instrument vendor or purchase a 'compatible' product from a third party plastics manufacturer or lab supplier. Increasingly, the potential for cost savings is attracting some users to source third party tips.

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3D Cellular Imaging - Advances and Considerations for High-Content Screening By O. Joseph Trask, Dr Daniel V. LaBarbera and Dr Kevin Quick
Commercially available high-content imaging (HCI) systems, introduced in the 1990s, have provided the scientific community with a platform that offers a unique set of tools ideal for advancing high-throughput biological discoveries and therapeutic development.

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CRISPR Cas9: Transforming Gene Editing in Drug Discovery Labs By Dr John Comley
It is evident from a recent market survey on gene editing in drug discovery that CRISPR/Cas9 is now recognised as the superlative method when attempting a gene knockout or when introducing defined mutations, insertions or modifications to the genome.

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Full Length Isoform Sequencing (Iso-Seq) Yields a More Comprehensive View of Gene Activity By Luke Hickey
RNA-seq has revolutionised how scientists can interrogate gene expression. But after years of performing RNA-seq studies with short-read sequencers, many have realised that there is more to be discovered.

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I Robot. I, The Future - Robotics Within and Beyond The Lab Richard Holland
The Pistoia Alliance (whose membership includes most of the world’s major pharmaceutical companies, technology vendors and publishers active in the life science R&D sector), is keenly interested in discovering the ways in which innovation through pre-competitive collaboration can be used to explore and exploit the constant stream of new technologies that become available.

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With Synthetic Biology, Drug Discovery Is Going Virtual by Christopher Voigt
Christopher Voigt is a professor of biological engineering at the Massachusetts Institute of Technology, where his lab focuses on synthetic biology. Two major areas of interest for him are developing a genetic programming language for cells and applying synthetic biology to biotechnology challenges.

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Metabolomics - A Playbook for Functional Genomics By Dr David Ferrick
If we have learned anything from scientific research in the last 20 years, it is that finding cures to complex diseases is difficult. Despite the promise of the genomic revolution, disease progression and patient outcomes are still not easily predicted by genetic factors alone.

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The Coming Age Of Mass Spectrometry Imaging By Dr Peter J.H. Webborn and Dr Richard J.A. Goodwin
Mapping complex drug distribution/retention in tissues, aligned with efficacy and safety biomarker localisation is now possible using label-free mass spectrometry imaging technologies.

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Microtissues For In Vitro Toxicity Assessment: Cost effective and in vivo relevant toxicology tools By Dr Stephanie Ravenscroft, Dr Caroline Bauch, Dr Laura Hinton and Dr Paul Walker
Conventional two-dimensional (2D) cell models (adherent cells grown on cell culture plates or cells in suspension) are limited in their abilities to accurately predict clinical toxicity since they lack the fundamental complexity of in vivo tissue environments. As a result efforts are being directed towards more sophisticated multicellular three-dimensional (3D) cell models with improved in vitro to in vivo correlation.

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Preclinical Imaging: Improving Translational Power In Oncology By Dr Todd Sasser
Imaging has long been indispensable in clinical practice, and researchers have for many years used the same toolbox of imaging modalities as a component of their preclinical and drug development work.

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Enabling Technologies
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