Drug Discovery
This section features DDW articles on drug discovery and drug development.
Page 1 to 14 of 76 |     NEXT PAGE >
How Phenotypic CRISPR Screening is Revolutionising Drug Discovery By Dr Steffen Lawo and Dr Carlos le Sage Fall 2018
Research in drug discovery and biotechnology increasingly exploits gene editing at industrial scale in order to identify and validate new biological targets for precision medicines. The discovery of CRISPR-Cas9 systems has fuelled a rapid expansion of gene editing adoption with particular interest in the increasingly prevalent area of functional genomic screening.

Read More

Genetically-Engineered Models: The Value of Precious GEMs By Dr Megan M. MacBride Fall 2018
Genetically-engineered animal models (GEMs) are critical tools for drug discovery and development, but intellectual property (IP) concerns can complicate access.

Read More

The Future Of Drug Discovery - Cutting-edge technologies meet traditional paradigms in assay development By Dr Roger Bosse Fall 2018
With more than 1,500 drugs approved by the Food and Drug Administration (FDA) on the market, the easiest disease targets are already covered (1). Today’s scientists are challenged to find new compounds, acting alone or in combination, on intractable targets to treat multicausal diseases including cancers, metabolic and psychiatric disorders.

Read More

The Mass Spectrometry Innovations Simplifying Drug Discovery Workflows Helen Stewart-Miller and Dr Richard Massey Summer 2018
Mass spectrometry (MS) has long been a valuable tool for drug discovery, and steady advances in its capabilities and performance have generated powerful insights for the pharmaceutical industry. The latest MS innovations are now helping biotherapeutics developers overcome challenges around sample preparation and large molecule analysis.

Read More

The Cancer Conundrum - Increasing Clinical Success In Early Stage Drug Discovery By Lubna Hussain Spring 2018
This article focuses on increasing clinical success in early stage drug discovery, by implementing improved methodologies in the early phase & using primary cells and 3D culture models to enhance cancer drug discovery.

Read More

How High-Throughput CRISPR is set to Deliver Knockout Performance in Drug Discovery By Dr Paul Avery and Dr Richard Massey Spring 2018
CRISPR-Cas9 has rapidly transformed our ability to perform targeted gene editing. While the technique has received much interest for its potential in the field of gene therapy, advances in its high-throughput use mean it can now open up a wealth of opportunities in drug discovery too.

Read More

Kinases - Application of New Assay Technologies to Shed Light on Kinase Drug Discovery By Dr Gary Allenby Spring 2018
The human kinome comprises 518 known protein kinases and more than 20 lipid kinases. Nearly all aspects of control within a cell are modulated by reversible phosphorylation of proteins, mediated by protein kinases.

Read More

High-Throughput Spheroid Culture By Hilary Sherman, Dr Richard M. Eglen & Audrey Bergeron Winter 2017/18
The cost of drug development is becoming unsustainable, partly due to the high attrition rate of drugs in clinical trials.

Read More

Breaking down silos in drug development - why interdisciplinary integration is fundamental for pharma's future By Dr Paul Overton Winter 2017/18
A silo mentality is an issue for any organisation, but it is particularly problematic for the pharmaceutical industry. Drug development is a multidisciplinary endeavour that relies on the cumulative efforts of highly skilled teams in order to be successful. Yet these teams cannot work in isolation.

Read More

Practicalities of conducting REPLICATION STUDIES in Preclinical Cancer Biology By Dr Nicole Perfito, Dr Rachel Tsui & Dr Elizabeth Iorns Winter 2017/18
The first results for the Reproducibility Project: Cancer Biology offer insights into the time and cost of conducting replication studies in preclinical cancer biology.

Read More

Drug Discovery in the Age of Big Data - The Impact of RNAi & CRISPR/Cas9 Technologies By Dr Prem Premsrirut Fall 2017
How RNA interference and CRISPR/Cas9 technologies are helping to build better mouse models and push drug discovery into a new era.

Read More

How The B6 Mouse Strain is Revolutionising Drug Discovery By Dr Philip Dube Fall 2017
Inbred mice are critical tools in biomedical research and one particular strain, known as C57BL/6 (Black 6 or B6, for short), is rapidly becoming the standard model for many applications and revolutionising modern research.

Read More

Advancing the Drug Discovery Pipeline with Early Stage In Vitro ADME and Toxicity Testing By Dr Maureen Bunger Summer 2017
With increasing pressures on pharmaceutical companies to develop new, effective therapeutics across the board, and keep the costs of development down, the drug discovery industry needs to ensure that its standard processes and procedures are as streamlined and effective as possible.

Read More

Drug Discovery
Page 1 to 14 of 76 |     NEXT PAGE >