Webinars on Demand

Harnessing the power of IgE antibodies to create novel therapeutics

From human B cells to engineered antibodies, IgGenix is taking a novel approach towards breaking through the last frontier of immunology: allergies. By reengineering key antibodies in the allergic cascade, this biotech company is developing a first-in-class therapy for the millions of people whose daily lives are limited by food allergies and other severe allergic […]

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Accessing broad B cell diversity to rapidly identify high-value rabbit monoclonal antibodies

Opto B Discovery on the Beacon optofluidic system is designed to enable rapid selection of lead candidates by function-forward screening of B cells in under one week. This presentation will introduce Berkeley Lights’ newest antibody discovery workflow, the Opto Memory B Discovery workflow, and share how customers are using the workflow to screen rabbit memory […]

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Embedding quality into cell line development through the application of an innovative picodroplet-based single cell sorter

Generation of a highly expressing, regulatory acceptable clonal cell line is the first key activity in the development of a biopharmaceutical. Cell line development is labour intensive, time consuming and costly and is subject to stringent regulations to ensure patient safety. All cell lines used to produce clinical batches of biopharmaceuticals are required to conform […]

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Broadening drug discovery: Use of unperturbed, native state cells to uncover true biological targets at single-cell level

Extensive manipulation, mechanical force, and labelling methods used to enrich cells activate transcriptional programs that mask molecular profiles truly significant to any underlying disease. The consequence is identification of drug targets that are not relevant to the biological process under study. Based on Nakhoda and Olszanski, 2022 (Addressing Recent Failures in Immuno-Oncology Trials to Guide […]

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Early phase support for plasmid DNA supply to secure future manufacturing

One critical bottleneck in Cell and Gene Therapy (CGT) manufacturing is the production of high-quality plasmid DNA (pDNA), a vital building block for mRNA-based vaccines, viral vector-based cell or gene therapies that require pDNA as a starting material. Building a robust supply of GMP-grade pDNA requires that quality be a focal point of the production […]

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Reveal the best drug targets with Engineered Cell Libraries

CRISPR-based knockouts are the gold-standard genetic perturbation method in target identification and validation. However, efficient CRISPR knockout editing and transfection for arrayed screening require specialised skills and infrastructure that your organisation may not have. What if you could receive ready-to-use CRISPR-edited cells without needing to handle, optimise, and transfect your CRISPR library?  In this on-demand […]

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Innovative assays for neurodegeneration drug discovery programs

Neurodegenerative diseases are characterised by neuronal damage, degradation of the blood-brain barrier and failures in the normal repair mechanisms of the brain. Many of the most promising areas of drug development in this field target neuroinflammation and remyelination. In this on-demand webinar, presented by Dr Elise Malavasi, Principal Scientist at Concept Life Sciences, we use […]

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High resolution electron cryo-microscopy: From membrane proteins to diseases

Watch the webinar High resolution electron cryo-microscopy: From membrane proteins to diseases, supported by Thermo Fisher Scientific.  The webinar demonstrates how cryo-EM is impacting high resolution structure biology from membrane proteins to diseases including Alzheimer’s disease and cancer therapeutics by showing high-resolution structures of these proteins bound to inhibitors.  It is presented by Dr Abhay Kotecha, […]

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Utilising novel sample preparation techniques to enhance Cryo-EM structural analysis 

Cryo-EM has been adopted into drug discovery workflows by the pharmaceutical and biotechnology industries having proved itself capable of delivering atomic resolution structures for key targets, including integral membrane proteins such as GPCRs and ion channels.   More recently, significant improvements in throughput have seen use of the technique expand quickly within the sector. Key to […]

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An introduction into fragment-based drug discovery: webinar

Fragment-based drug discovery (FBDD) is a method used for finding hit compounds as one strategy of hit identification (hit ID) in the drug discovery process.   Introduction into Fragment Based Drug Discovery, hosted by DDW and supported by WuXi AppTec, is now available to watch online.  Fragments are small molecules with a low molecular weight (less […]

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Tips and Tricks on Obtaining Quality Data from Biosensors for Cell Signalling Assays

Tips and tricks on how to obtain and analyse high quality data from live cell, high throughput assays of signaling dynamics. Genetically encoded fluorescent biosensors enable continuous recording of cellular signaling in live cells. This breakthrough technology provides unprecedented, real-time measurements of signaling dynamics, which is emerging as a critical determinant of physiological function and […]

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High throughput Octet BLI applications in early monoclonal antibody discovery

Charles River, Antibody Discovery group, has integrated computational immunology, antibody engineering and phage display technologies into its comprehensive antibody discovery platforms that rapidly deliver antibody hits or optimised variants with a range of affinities, cross-species coverage, and improved drug-like characteristics. Charles River uses label-free biosensors and other bioanalytical assays to support biochemical/biophysical characterisation of biotherapeutic […]

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Transforming lab automation for cellular applications

Automation has long been a buzzword associated with cutting-edge science, yet even in the most advanced labs it is usually only applied to specific assays and methods. However, by building automation across your full laboratory workflows and integrating it into existing protocols, Biotech R&D can be transformed. In this webinar, titled ‘Transforming lab automation for cellular […]

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Resolving complex biology with single cell and spatial multiomics

Single cell and spatial tools from 10 X Genomics are designed to deliver powerful, multiomic insights from complex disease samples that enable you to confidently fuel your target identification pipeline with the most promising candidates. Resolving complex biology with single cell and spatial multiomics was presented by Stephen Hague, Managing Lead Science & Technology Advisor […]

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AI in action: examples of AI across drug discovery

Drug discovery and development is a challenging multiparameter optimisation problem. Harnessing the power of artificial intelligence (AI) can help accurately predict the behaviour and properties of small molecules. In this on-demand webinar from X-Chem you will see: How AI and DNA-encoded library (DEL) screening are transforming early phase drug discovery How this can impact all stages […]

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Generating and validating critical antibody reagents

Antibodies are critical reagents applied in multiple biological areas, such as scientific research, therapeutics, and diagnosis. High-quality and reliable antibody reagents are the foundation of good assay performance. To learn more generating and validating critical antibody reagents view this free event hosted by DDW and supported by Sino Biological. The webinar took place on 16 June […]

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