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Innovating now to reinvent the future of drug discovery
This is the latest episode of the free DDW narrated podcast, “Innovating now to reinvent the future of drug discovery”. It covers three articles written for Volume 23, Issue 2 – Spring 2022 of DDW. They are called “Predictive biomarkers in the age of spatial biology”, “Exploiting the microbiome to drive nature – inspired innovation”, […]
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Application of bioinformatics in support of precision medicine
Bioinformatics has played a major role in gene sequencing diagnostics and has been an essential tool to investigate the genetic causes of disease. With the support of new technologies and tools, bioinformatics can play an important part in the support and continued development of precision medicine. By Mike Furness and John Wise
Listen now3D Organoid Cell Culture – Optimising disease models for research and drug discovery
In this episode, we examine the use of 3D organoid cell culture systems as applied to cancer research and the development of novel anti-oncologic drugs. Collectively, this transition from 3D spheroid culture to organoid culture allows researchers to generate multiple organ-specific cell types, resulting in cell architectures that more closely resemble the human tissue microenvironment. […]
Listen nowBitten by the Bug – A flurry of investments fuel microbiome drug discovery
It has become quite evident that the microbiome has the potential to impact drug discovery in vital ways. In addition to impacting study reproducibility and variability, the microbiome may influence drug efficacy or serve as a therapeutic agent. To capitalise on the microbiome’s potential to improve human health, biotech and pharmaceutical companies are devoting greater […]
Listen nowFrom Genotype to Phenotype: Leveraging functional genomics in oncology
Drug discovery is increasingly informed by genomics, which can significantly boost the chances of a novel therapy successfully navigating the lengthy journey from bench to bedside. But despite the rapid proliferation of genomic information, we still have a limited understanding of how specific genes and genetic variations drive tumour growth and therapeutic resistance. In turn, […]
Listen nowFlow Cytometry – The advanced systems overcoming drug discovery pain points
Flow cytometry is an invaluable technique for the characterisation of highly heterogeneous cell populations. Thanks to improvements in throughput, automation and multichannel detection capabilities, recent years have seen its use expand across a wide range of drug discovery applications. In this article, we look at novel developments in flow cytometer reagent and instrument design, and […]
Listen nowCell Therapy – Falling short of its potential?
Despite major investment in the field, few cell therapies have gained regulatory approval with limited commercial success. The success of therapeutic products is defined by three factors: safety, efficacy and scalability. Achieving these for cell therapy presents new challenges; overcoming transplant rejection (and GvHD in the case of immune cells), producing and culturing functional cells […]
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