Editor’s Choice

The US Food and Drug Administration has published draft guidance with updated recommendations for good clinical practices (GCPs) to modernise the design and conduct of clinical trials. The updates are intended to help pave the way for more efficient clinical trials. The draft guidance is adopted from the International Council for Harmonisation’s (ICH) recently updated […]

Researchers from the University of Manchester and Link Biologics have revealed preclinical data on a potential new treatment for osteoarthritis. The results were published in a paper in journal Osteoarthritis and Cartilage, which describes the development of a protein biological drug termed Link_TSG6 with disease modifying properties. Osteoarthritis (OA) is the most common form of […]

New study results show that an experimental drug may prevent or slow vision loss in people with diabetes. The researchers at Wilmer Eye Institute, Johns Hopkins Medicine used mouse as well as human retinal organoids and eye cell lines in their investigations. Eye conditions that cause vision loss are common complications of diabetes, affecting nearly […]

Immuno-oncology company Aulos Bioscience has revealed interim results from an ongoing Phase I/II trial of monoclonal antibody AU-007 in solid tumours. The data indicate that AU-007 is well tolerated in patients with unresectable locally advanced or metastatic cancer and there are early signs of anti-tumour activity. AU-007 is a human IgG1 monoclonal antibody designed using […]

Scientists are calling for tighter regulation of stem cell treatments, claiming clinics worldwide are offering unproven ‘therapies’ for conditions as varied as hair loss and Parkinson’s. Researchers at the University of Reading and the Universiti Sains Malaysia have identified 114 companies in over 20 countries offering unproven, unregulated, stem-cell derived products to consumers. They are […]

Several new products for the life sciences sector have been launched over the last month, from miniature semiconductor chip (MSC) technology to a new inhalation testing service. DDW provides an update. GenScript Biotech Corporation: GenTitan Gene Fragments Synthesis service Powered by GenScript’s miniature semiconductor chip (MSC) technology, GenTitan gives scientists access to high-throughput, synthetic DNA, […]

The UK government will invest up to £39 ($48) million in antimicrobial resistance (AMR) research through the Global AMR Innovation Fund (GAMRIF). The funding includes up to £25 ($30.9) million awarded to support the early development of new antibiotics, vaccines, rapid diagnostics and other products to combat life-threatening drug-resistant infections. The money will bolster the […]

UK researchers at the Francis Crick Institute, Imperial College London and AstraZeneca will advance the discovery of new ‘molecular glues’ to treat a range of different diseases, thanks to a £11.2 million combined investment. The investment includes a Prosperity Partnership grant from the Engineering and Physical Sciences Research Council (EPSRC) and matching funds from AstraZeneca. […]

The countdown for Future Labs Live has begun. The event is set to take place in a week’s time, covering topics across the whole lab ecosystem, from facilities, to training and development, to automation and digital transformation. With over 200 speakers confirmed and 2000 registrations, this is an event you do not want to miss.   […]

A first-in-human clinical trial of an experimental oral drug for removing radioactive contaminants from inside the body has begun. The trial is testing the safety, tolerability and processing in the body of escalating doses of the investigational drug product HOPO 14-1 in healthy adults. The National Institute of Allergy and Infectious Diseases (NIAID), part of […]

A study that could lead to the development of new treatments for Parkinson’s disease has launched at the University of Dundee, Scotland. The study is utilising LRRK2 inhibitors developed by Denali Therapeutics and Biogen. Mutations in the LRRK2 protein kinase are the most frequent cause of inherited Parkinson’s disease and it is hoped that an […]

Researchers at Université de Montréal have discovered a way to potentially restore vision in patients suffering from degenerative retinal disease. Published in Proceedings of the National Academy of Sciences, the research was led by UdeM medical professor Michel Cayouette, Director of Cellular Neurobiology Research at the UdeM-affiliated Montreal Clinical Research Institute. His research team discovered […]

The US market for medicines grew by 5% in 2022, reaching a total value of $429Bn on a net price basis. This was driven by a range of factors, including an increase in health services utilisation, which is now back to pre-pandemic levels, and the entry of new medicines into the market. Balancing these drivers […]

Researchers from the University of Oxford have reported findings from a Phase II clinical trial investigating the efficacy of an investigational treatment against long Covid fatigue. The study found that participants given the treatment, AXA1125, developed by US pharmaceutical company Axcella Therapeutics, felt less fatigued than those given a placebo. Emerging data on long Covid […]

A National Institutes of Health (NIH) clinical trial was stopped early because a daily statin medication was found to reduce the increased risk of cardiovascular disease among people living with HIV. This was the first large-scale clinical study to test a primary cardiovascular prevention strategy in this population. Advances in HIV treatment have drastically reduced […]

The Spring 2023 issue of Drug Discovery World Magazine is out now. Featuring a Therapeutic Spotlight on Neuroscience, the magazine is available to download free here and read for free on the DDW App. You can also request to receive a copy of the printed magazine here. Key features of the Spring issue include a market report on the US drug discovery […]