Whitepapers

The development of a successful PROTAC candidate requires overcoming challenges at each stage of development. Read this guide to learn about common roadblocks, technologies to overcome them, and how to ensure you’re on the right track to building an efficient protein degrader. Download this guide to learn about: The most common roadblocks at key stages […]

Download our mitochondrial toxicity infographic and discover the benefits of novel in vitro strategies for consumer safety. Drug-induced mitochondrial dysfunction has been linked to compound attrition, organ toxicity, black-box warnings, and market withdrawals. Our infographic will help you: Gain an historical perspective on mitochondrial toxicity. Understand the importance of testing in early-phase drug discovery. Learn […]

Monitoring neuronal morphology in long-term in vitro cell cultures is critical for characterisation and evaluation of disease models and to understand neuronal development. Ideally, approaches to track neurite dynamics would allow continuous automated measurements of structural parameters, including neurite length and number of branch points. These methods should be non-perturbing and enable quantification of neurons […]

Make your iPSC-derived glutamatergic neuron cultures a success every time with these tips from a neuronal cell culture expert. In this Guide, you will learn: How to prevent glutamatergic neurons from detaching from culture surfaces How to formulate extracellular matrix coatings to promote cell adherence The best timings for media changes, especially when the unexpected […]

Cell therapy research has never been more exciting with all of the research ongoing. Learn more about the trends, insights, and perspectives from ACROBiosystems as a manufacturer of cell therapy reagents, including topics like: CAR-NK research Developing new CAR constructs Evaluation CAR expression detection Role of GMP Manufacturing in cell therapy

Given the potential of emerging advanced therapies, market demand is likely to continue to grow. Generating the required quantity of cells efficiently becomes even more challenging when the cells of interest are attachment-dependent, such as induced pluripotent stem cells (iPSCs). The choice of cell culture platform will have significant operational and commercial impacts. Download this […]

Download this exclusive cell and gene therapy guide to learn about: The successes of cell and gene therapies plus the biggest questions facing the sector Expert views on the challenges and opportunities for cell and gene therapies in 2023 Understanding future road maps of cell and gene therapies Why there are two sides to the […]

This is an extraordinarily exciting time to be involved in precision medicine for cancer. This new whitepaper reviews some of the topics and trends in this emerging research area, including: 3D cultures: Spheroids and organoids Organoids in cancer research Tumour microenvironments Organ-on-a-chip and body-on-a-chip 3D bioprinting

Currently, no effective cure or treatment for Huntington’s disease exists. To accelerate Huntington’s disease research and drug discovery, researchers need access to physiologically relevant human disease models that recapitulate patient phenotypes, in combination with more advanced methods to understand the underlying mechanisms of the disease. In this App Note you will learn: How Charles River […]