Understanding T cell phenotype and function to enable improved therapeutics

The human body has the capacity to produce an array of specialized T cells, which provide unique responses to a diverse range of tumor cells and pathogens. The modulation of T cells is an exciting prospect for the development of novel therapies for immuno-oncology –autoimmune applications, adoptive cell therapy and vaccine development.

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Accurate affinity profiling of a SARS-CoV-2 antibody in serum

The ability to accurately characterise the immune response against SARS-CoV-2 is of vital importance in managing the current COVID-19 pandemic. Measuring antibody affinity under physiologically relevant conditions in complex mixtures like serum remains challenging but is critically important to furthering our understanding of the immune response and protection window in patients and vaccinated individuals. In […]

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Syngeneic mouse models for preclinical immuno-oncology

The advent of immuno-oncology has necessitated changes in the types of animal models used in oncology drug discovery. Syngeneic models—inbred mice bearing an engrafted tumour derived from a genetically identical mouse strain—are invaluable preclinical research tools that enable tumor studies in the context of a complete and functional immune system. These models are powerful tools […]

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OMNImet™·GUT: enables at-home collection and ambient temperature transport of fecal samples for metabolomics

In this whitepaper, Metabolon describes the evaluation of OMNImet™·GUT as an at-home collection device for ambient temperature transport of samples for fecal metabolomics analysis. Compatibility with Metabolon’s global metabolomics platform and quantitative SCFA assay is also demonstrated.

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Live-Cell Analysis Training Video: From Culture to Assay

Cell-based assay research in pharma and academia, depends on forms of measurement of living cells. As soon as cells are placed in culture, there is opportunity to learn about or monitor the cells prior to analysis. Live-Cell Analysis enables real-time analysis with full cell tracking workflows.

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Guide: 5 Ways Biophysical tools help brain studies

Guide: 5 Ways Biophysical tools help brain studies Sponsored by Nanotemper, 8 June 2020 Learn how scientists gain insight into the molecular mechanisms of protein misfolding and aggregation- a hallmark of neurodegenerative diseases by using biophysical tools to analyze molecular interactions and thermal stability. This eBook looks at research from five peer-reviewed publications. If you […]

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New antibody internalization advanced screening method provides greater speed & insight

New antibody internalization advanced screening method provides greater speed & insight 26 May 2020 Sponsored by Sartorius Researchers abilities to improve the breadth of therapeutic antibodies have been aided by innovative technologies for antibody discovery, for instance, through humanization of mouse antibodies and phage display. However, advanced antibody design techniques create the need for new […]

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