Systems-level analyses reveal that children with the COVID-associated inflammatory syndrome, MIS-C, display a unique immunological profile

Olink has created a summary article of a study recently published by Consiglio et al. in Cell. This study focuses on the rare cases when children develop Multisystem Inflammatory Syndrome in Children (MIS-C) in response to infection by the SARS-CoV-2 virus. Typically in these cases the syndrome manifests four to six weeks after infection, producing […]

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White paper: Improve the drug discovery tool box

Making good decisions in the drug discovery process requires software to effectively manage the size and complexity of multiparametric datasets. Companies that most quickly and accurately identify key drug discovery parameters will win the race to identify the most appropriate targets and develop medicines to affect them.

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Automation that connects your drug discovery workflow

Scientific and technological advancements continue to emphasise the importance of automation, both in the physical and digital world. Given recent discussions about the lab of the future, the benefits have expanded to highlight how automation can support greater connectivity between data and workflows, paving the way to a ‘smarter lab’. A fully integrated robotic platform […]

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Your guide to fragment-based drug discovery

Fragment-based drug discovery (FBDD) is one of the most popular approaches for finding lead compounds and it is becoming more widely adopted by pharma companies. FBDD is the solution researchers turn to when faced with challenging targets that call for compound libraries that offer more diverse molecules — especially from new chemical spaces. More importantly, […]

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App Note

Maximize your productivity with high-throughput flow cytometry automation

High-throughput flow cytometry technologies have revolutionized drug screening, says Bio-Rad. This application note explains how you can take throughput and reproducibility to the next level using the ZE5 Cell Analyzer. In the current environment, with increased pressures on drug companies, Bio-Rad believes using effective automation is critical. Featured in this application note: How integration of […]

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Linking genomics with proteomics to accelerate the search for drug targets

A summary of three recently published research studies that highlight the importance of linking genetic and protein expression data in the context of disease phenotypes in order to identify new, robust drug targets. While many drugs are developed based on genomic findings, it’s common for these drugs to fail in the clinical phase due to […]

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Horizon’s iPSC cell line engineering services

Horizon can help researchers work with the biologically relevant cell models (immune cells, induced pluripotent derived cardiac and neural cells, and organoids) that closely mimic the end-stage biology of interest. With over a decade of CRISPR/Cas cell line engineering experience, Horizon’s iPSC editing platform is designed to enable efficient and precise genomic modifications in a […]

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App note

A rapid method to quantitatively screen bispecific antibody using protein A and His1K biosensors

Recent biotechnological advances have fueled development bispecific antibodies (bsAbs) in the last 10 years. However, the functional analysis of bsAbs during bioprocessing adds a challenge for scientists given the wide array of bsAbs populated by many different species, comprising many different formats, and that traditional SPR and ELISA methods for bsAbs evaluation are time consuming. […]

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Understanding T cell phenotype and function to enable improved therapeutics

The human body has the capacity to produce an array of specialized T cells, which provide unique responses to a diverse range of tumor cells and pathogens. The modulation of T cells is an exciting prospect for the development of novel therapies for immuno-oncology –autoimmune applications, adoptive cell therapy and vaccine development. Download here

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App note

Accurate affinity profiling of a SARS-CoV-2 antibody in serum

The ability to accurately characterise the immune response against SARS-CoV-2 is of vital importance in managing the current COVID-19 pandemic. Measuring antibody affinity under physiologically relevant conditions in complex mixtures like serum remains challenging but is critically important to furthering our understanding of the immune response and protection window in patients and vaccinated individuals. In […]

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