Articles

Opportunity knocks: why high quality leads matter

3 September 2020 , By Dr Phil Jones

Does every cloud have a silver lining? Dr Phil Jones, Chief Scientific Officer, BioAscent Discovery outlines the opportunities for lead generation and the acquisition of compound screening libraries. The discovery of novel medicines is a complex but vital endeavour. The range of approaches being used to identify those new medicines is ever widening with, for […]

How to achieve data-driven R&D at speed

1 September 2020 , By Matt Jones

COVID-19 has shown the pace of innovation that is possible to develop vaccines and therapeutics. Matt Jones, Lead Data Scientist Strategist, Tessella explains how to set up R&D and data science teams to keep that going. The drive to develop new therapeutics and vaccines for COVID-19 saw researchers move at unprecedented speeds. Years became months, […]

Race To COVID-19 cure – the Core Model for solving the pandemic crisis (Part 1 & 2)

29 August 2020 , By Ibis Sanchez-Serrano and Rathnam Chaguturu , Volume 21 Issue 3 - Summer 2020

By Ibis Sanchez-Serrano and Rathnam Chaguturu Mitigation of COVID-19 pandemic requires a combination of effective epidemiological policies and the discovery/development of powerful drugs against the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) that causes this disease. This article examines the major initiatives being explored at the public policy level to contain the spread of COVID-19 […]

Will the next generation of CAR-T cells be modified using base editing?

21 August 2020 , By Dr Jamie Freeman , Volume 21 Issue 3 - Summer 2020

Will the next generation of CAR-T cells be modified using base editing? By Dr Jamie Freeman Volume 21 Issue 3 – Summer 2020 Base editing is a potentially transformative technology for engineering DNA in cells that has the potential to generate knockouts or correct certain errors or mutations in the DNA for applications such as […]

THE COVID-19 RACE how mouse models will help researchers cross the finish line

20 August 2020 , By Dr Megan MacBride , Volume 21 Issue 3 - Summer 2020

THE COVID-19 RACE how mouse models will help researchers cross the finish line By Dr Megan MacBride Volume 21 Issue 3 – Summer 2020 The emergence of SARS-CoV-2 virus and the disease it causes, COVID-19, have fuelled significant shifts in preclinical research across the globe. Amid the worldwide health emergency created by high infection rates, […]

HIGH CONTENT SCREENING IN ACTION a powerful tool to identify novel antivirals and vaccines

17 August 2020 , By Dr Karin Bottcher , Volume 21 Issue 3 - Summer 2020

By Dr Karin Bottcher Volume 21 Issue 3 – Summer 2020 High content screening (HCS) has played a significant role in infectious disease research and drug discovery to date and can be a strong tool in the age of COVID-19 and beyond. With a focus on viral diseases, this article will describe how HCS has […]

Could new manufacturing technologies finally make the promise of stem cell therapies a reality?

16 August 2020 , By Dr Ross Macdonald , Volume 21 Issue 3 - Summer 2020

Could new manufacturing technologies finally make the promise of stem cell therapies a reality? By Dr Ross Macdonald Volume 21 Issue 3 – Summer 2020 Cell-based therapies are being widely recognised for their potential to treat a variety of medical conditions, but they face major obstacles toward commercialisation. Traditionally, they have been difficult and expensive […]

Honing in on perfect targeting

13 August 2020 , By Dr Samantha Zaroff , Volume 21 Issue 3 - Summer 2020

Honing in on perfect targeting By Dr Samantha Zaroff Volume 21 Issue 3 – Summer 2020 The pros and cons of different delivery modalities for personalised cancer vaccines. Introducing neoantigens directly into a patient in order to elicit an anti-tumour killing immune response is known as personalised cancer vaccine therapy. Currently, there is a huge […]

The COVID-19 antiviral race: we’re all in this together

12 August 2020 , By Uduak Grace Thomas , Volume 21 Issue 3 - Summer 2020

The COVID-19 antiviral race: we’re all in this together By Uduak Grace Thomas Volume 21 Issue 3 – Summer 2020 In response to the COVID-19 pandemic, international scientists from academia and industry have pooled their expertise and resources to identify candidate compounds that inhibit the activity of the SARS-CoV-2 main protease, in order to develop […]

Creating VACCINES drop by drop

9 August 2020 , By Richard Gray , Volume 21 Issue 3 - Summer 2020

Creating VACCINES drop by drop By Richard Gray Volume 21 Issue 3 – Summer 2020 The recent outbreak of COVID-19 has highlighted the need for fast and efficient development and production of vaccines for a whole gamut of pathogens, old and new. Microfluidics technologies can be used to accelerate the vaccine development process in a […]

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