Enabling Technologies

Creating vaccines drop by drop

9 August 2020 , By Richard Gray , Volume 21 Issue 3 - Summer 2020

By Richard Gray The recent outbreak of COVID-19 has highlighted the need for fast and efficient development and production of vaccines for a whole gamut of pathogens, old and new. Microfluidics technologies can be used to accelerate the vaccine development process in a number of ways, not least in the directed evolution of the strains […]

Meeting analytical challenges in a brave new world of next generation biotherapeutics

24 April 2020 , By Mani Krishnan and Susan Darling , Volume 21 Issue 2 - Spring 2020

Meeting analytical challenges in a brave new world of next generation biotherapeutics By Mani Krishnan and Susan Darling Volume 21 Issue 2 – Spring 2020 The need for innovative advanced analytical tools to accelerate the development of immunotherapies and other complex biologics that may one day cure genetic diseases and cancer has never been greater. […]

Innovative glycan imaging methods drive cancer biomarker discovery

12 April 2020 , By Dr Richard Drake, Dr Anand Mehta and Dr Peggy Angel , Volume 21 Issue 2 - Spring 2020

Innovative glycan imaging methods drive cancer biomarker discovery By Dr Richard Drake, Dr Anand Mehta and Dr Peggy Angel Volume 21 Issue 2 – Spring 2020 Glycosylation accounts for the majority of post-translational modifications (PTMs) of proteins, and changes in glycosylation are known to play a key role in disease state. Novel mass spectrometry (MS) […]

Getting a handle on liquids: automation solutions for drug discovery

23 December 2019 , By Helen Stewart-Miller and Thomas Hope , Winter 2019/20

Getting a handle on liquids: automation solutions for drug discovery By Helen Stewart-Miller and Thomas Hope The accurate and precise measurement of liquids and the transport of exact volumes between vessels, or from one instrument to another, are processes that constitute the very essence of research. However, while this simple requirement for the meticulous handling […]

Automating Automation – How close are we to Artificial Intelligence impact?

23 August 2019 , By Dr Michael A. Tarselli, Dr Yohann Potier and Dr Alan E. Fletcher , Summer 2019

Automating Automation – How close are we to Artificial Intelligence impact? By Dr Michael A. Tarselli, Dr Yohann Potier and Dr Alan E. Fletcher In terms of consistency, repeatability, known errors and sheer volume, there exists perhaps no better collection of data for computer learning than that emerging from automated processes. Many common lab procedures […]

Automated Cell-based Assays: Novel tools overcome the barriers to drug discovery success

13 August 2019 , By Helen Stewart-Miller and Kate Tointon , Summer 2019

Automated Cell-based Assays: Novel tools overcome the barriers to drug discovery success By Helen Stewart-Miller and Kate Tointon In this article, we look at how commercial products and services are facilitating the automation of cell-based assays to advance drug discovery and accelerate the delivery of new medicines to patients. Cell-based assays are vital tools in […]

Safety First – Automating cell line development

3 August 2019 , By Jon Newman-Smith , Summer 2019

Safety First – Automating cell line development By Jon Newman-Smith Developing and maintaining cell cultures in a stable and sterile environment is of paramount importance to protect samples and increase overall success of drug discovery pipelines. Cell lines are extremely fragile and susceptible to contamination which can be catastrophic in terms of both time and […]

How Advanced Automated Liquid Handling Systems are Reshaping Drug Discovery

8 December 2018 , By Helen Stewart-Miller and Dr Richard Massey , Winter 2018/19

How Advanced Automated Liquid Handling Systems are Reshaping Drug Discovery By Helen Stewart-Miller and Dr Richard Massey Winter 2018/19 Once the domain of high-throughput screening (HTS) applications, automated liquid handling systems are now used ubiquitously in drug discovery and have been fundamental in increasing throughput, driving efficiencies and improving standards of accuracy and reproducibility in […]

Microfluidics – Driving Innovation and Streamlining Single Cell Analysis

13 August 2018 , By Dr Frank F. Craig , Summer 2018

Microfluidics – Driving Innovation and Streamlining Single Cell Analysis By Dr Frank F. Craig Microfluidics platforms that harness picodroplet technology (picolitre volume aqueous droplets in stabilised oil emulsions) are unlocking the potential of single cell analysis to enable exciting new discoveries and advances with the potential to transform scientific research, drug development and precision medicine. […]

Technology Innovation Will Help Prepare Drug Discovery for Smart Screening Era

26 December 2017 , By Dr Clive Green and Dr Philip Spencer , Winter 2017/18

Technology Innovation Will Help Prepare Drug Discovery for Smart Screening Era By Dr Clive Green and Dr Philip Spencer Drug discovery is undergoing a transformation powered by advances that magnitude more molecules and enable smarter selection of compounds. We are on the cusp of having previously unimaginable amounts of information about each target and many […]

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