Drug Discovery

The CELL CULTURE innovations increasing drug discovery success

8 August 2020 , By Helen Stewart-Miller and Abby George , Volume 21 Issue 3 - Summer 2020

The CELL CULTURE innovations increasing drug discovery success By Helen Stewart-Miller and Abby George Volume 21 Issue 3 – Summer 2020 ‘Fail early, fail fast’ has been a mantra in the pharmaceutical industry for several years and directly impacts the overall strategy of many drug discovery and development programmes. Yet, despite the drive to fail […]

Antimicrobial resistance threatens to undermine our healthcare system

15 April 2020 , By Dr Peter Jackson , Volume 21 Issue 2 - Spring 2020

Antimicrobial resistance threatens to undermine our healthcare system By Dr Peter Jackson Volume 21 Issue 2 – Spring 2020 The immediate global challenge to human health and our economic stability due to coronavirus acts as a stark reminder that infectious disease preparedness cannot be ignored. While antimicrobial resistance (AMR) does not present the imminent ‘tsunami’ […]

How sharing compound solubility data can advance drug discovery

9 April 2020 , By Andrii Lozoniuk , Volume 21 Issue 2 - Spring 2020

By Andrii Lozoniuk Volume 21 Issue 2 – Spring 2020 Gathering compound solubility data is a key step during drug discovery that helps ensure cost-effective screening, yet it is a long process and is often underestimated in terms of difficulty. Global sharing of such data can help pharmaceutical companies minimise unnecessary expenditures in terms of […]

Target discovery and drug development what comes after CRISPR?

6 April 2020 , By Benedict CS Cross , Volume 21 Issue 2 - Spring 2020

Target discovery and drug development what comes after CRISPR? By Benedict CS Cross Volume 21 Issue 2 – Spring 2020 For an area of research as important and impactful as drug discovery, it is surprising how often efforts in this field are directed by short-term trends. We have seen an abundance of new tools and […]

Drug development 2.0 – The partnership model in practice

31 December 2019 , By Dr Brian Sheehan and Marco Cerato , Winter 2019/20

Drug development 2.0 – The partnership model in practice By Dr Brian Sheehan and Marco Cerato Over the last decade there has been a fundamental shift in the way in which drugs are developed and brought to market. Some years ago, the industry started to see profits falling as research and development (R&D) costs continued […]

Cryo-EM accelerates drug discovery by delivering previously intractable structural insights

29 December 2019 , By Hans Raaijmakers, et al. , Winter 2019/20

Cryo-EM accelerates drug discovery by delivering previously intractable structural insights By Hans Raaijmakers, et al. Cryo-electron microscopy (cryo-EM), a powerful biophysical technique that can analyse molecular assemblies, is changing the paradigm in structure-based drug design. As targets become more challenging, solving structures of drug target molecules or biologics becomes increasingly difficult. Cryo-EM empowers drug discovery […]

Using Live-Cell Imaging Systems to Transform Perspectives in Drug Discovery

29 October 2019 , By Helen Stewart-Miller and Dr Kate Tointon , Fall 2019

Using Live-Cell Imaging Systems to Transform Perspectives in Drug Discovery By Helen Stewart-Miller and Dr Kate Tointon Live-cell imaging has transformed the study of cell behaviour and function. The technique allows researchers to monitor internal cell structures, interactions and processes in real-time, and over time. In drug discovery, understanding the dynamic processes of cells provides […]

Bitten by the Bug – A flurry of investments fuel microbiome drug discovery

15 October 2019 , By Dr Alexander C. Maue , Fall 2019

By Dr Alexander C. Maue It has become quite evident that the microbiome has the potential to impact drug discovery in vital ways. In addition to impacting study reproducibility and variability, the microbiome may influence drug efficacy or serve as a therapeutic agent. To capitalise on the microbiome’s potential to improve human health, biotech and […]

Fail Early, Fail Fast – A phenotypic rescue approach

25 August 2019 , By Dr Anne-Marie Zuurmond, et al. , Summer 2019

Fail Early, Fail Fast – A phenotypic rescue approach By Dr Anne-Marie Zuurmond, et al. New disease targets frequently emerge in literature, but the thorough target validation required to consider these targets for a drug discovery programme is often lacking. In pharmacological or genetic perturbation studies using complex biological assays, undesired off-target effects cannot be […]

Flow Cytometry – The advanced systems overcoming drug discovery pain points

6 April 2019 , By Helen Stewart-Miller and Dr Richard Massey , Spring 2019

Flow Cytometry – The advanced systems overcoming drug discovery pain points By Helen Stewart-Miller and Dr Richard Massey Flow cytometry is an invaluable technique for the characterisation of highly heterogeneous cell populations. Thanks to improvements in throughput, automation and multichannel detection capabilities, recent years have seen its use expand across a wide range of drug […]

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