BioNet and BIA Separations collaborate to develop mRNA vaccines 

BioNet and BIA Separations, now part of Sartorius, have developed an optimised mRNA manufacturing process.  

BIA’s expertise in chromatographic columns for mRNA purification combined with BioNet’s expertise in the product development of genetic vaccines have, since early 2021, enabled both teams to collaborate on the optimisation and upscale of a high-yield mRNA production process. 

The new process has been successfully applied to the production of mRNA in the fight against Covid-19. The mRNA vaccine, produced at BioNet’s manufacturing facility, was developed by Chula Vaccine Research Center, Thailand in collaboration with the University of Pennsylvania. 

Both BIA and BioNet are now collaborating on other projects aiming to increase development capabilities and production capacity of nucleic acid vaccines in Europe, Australia, and low-middle income countries. 

Hong Thai Pham, CEO, BioNet said: “We are very pleased to be collaborating with BIA Separations / Sartorius in developing and tech-transferring optimized mRNA vaccine manufacturing processes. When time is of the essence, it is crucial to be able to rely on key partners whilst maintaining the highest level of quality in every aspect of our work. We are also very proud that our team was able to produce two kinds of genetic vaccines (DNA and mRNA) and we look forward to expanding our partnership with the BIA Separations’ team on future projects.” 

Aleš Štrancar, Managing Director at BIA Separations, added: “We are proud to have been selected to support BioNet’s development strategy and it was a great pleasure to work on their plans to develop an mRNA process. Due to Covid restrictions all the work and tech transfer has been coordinated via teleconferences in the absence of physical meetings and training. Despite this, the manufacturing process was developed in just four months which is close to a miracle. This would not have been possible without BioNet’s highly experienced and motivated team. In addition, a special appreciation to our own teams which were, once again, able to develop the manufacturing process in record time”.  

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