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        Diabetic eye disease

        Experimental drug could prevent diabetic eye disease

        1 June 2023

        …associated with the expression of proteins that promote blood vessel production and leakiness. When they measured genes regulated by HIF in cells treated with 32-134D, they found that their expression…

        Monoclonal antibodies

        AI-designed monoclonal antibody ‘redirects’ the immune system

        31 May 2023

        …which suppress the immune system, to effector T cells and natural killer cells that can kill tumour cells.” The Phase I/II trial AU-007 is the first computationally designed human monoclonal…

        Sphere Fluidics team

        Sphere Fluidics reveals new branding at SLAS Europe

        25 May 2023

        …workflows to accelerate scientific discovery. The company’s platform, Cyto-Mine, uses picodroplet microfluidic technology and is capable of screening up to 40 million cells in several hours, while maintaining viability, to…

        ""

        Researchers modify anti-nausea drug to treat pain

        24 May 2023

        …to many G-protein coupled receptors because many of them show sustained signalling within cells, and therefore require drugs that can enter cells and block the receptors in endosomes,” said Bunnett….

        Pancreatic cancer

        Uridine discovery could lead to new pancreatic cancer therapies

        19 May 2023

        …phosphorylase-1 (UPP1) to produce a different form of sugar, ribose, which can fuel cancer cells. Knocking out the UPP1 gene in mice stopped pancreatic cancer cells from using uridine and…

        Influenza virus

        mRNA universal influenza vaccine enters clinical trials

        18 May 2023

        …virus spreads and evolves, a more stable portion, known as the stem, evolves very slowly and is very similar across many different types of the flu virus. By using the…

        AI

        AI provides new insight into preventing human disease

        17 May 2023

        A molecular machine, which plays an essential ‘cargo’ role in controlling the delivery of proteins to the surface of human cells has been identified using artificial intelligence (AI). The research…

        Institute of Cancer Research

        Ovarian cancer drug enters Phase II trials

        11 May 2023

        …while selectively targeting the alpha folate receptor (FRα), which is highly expressed in cancer cells compared to normal tissues across a variety of solid tumours. Over 90% of ovarian cancer…

        Structure of the eye

        New technique could restore vision in retinal disease

        11 May 2023

        …cells in the retina and transform them into neural-like cells that could ultimately be used to replace cells lost in retinal degeneration. “We have identified two genes that, when expressed…

        Bone cancer

        CureSearch to fund new study for aggressive paediatric bone cancer 

        10 May 2023

        …the molecule TGF-ß, which is produced by osteosarcoma cells and immune cells in the tumour microenvironment. The presence of TGF-ß dampens the ability of the patient’s immune system to eradicate…

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