…associated with the expression of proteins that promote blood vessel production and leakiness. When they measured genes regulated by HIF in cells treated with 32-134D, they found that their expression…

…which suppress the immune system, to effector T cells and natural killer cells that can kill tumour cells.” The Phase I/II trial AU-007 is the first computationally designed human monoclonal…

…workflows to accelerate scientific discovery. The company’s platform, Cyto-Mine, uses picodroplet microfluidic technology and is capable of screening up to 40 million cells in several hours, while maintaining viability, to…

…to many G-protein coupled receptors because many of them show sustained signalling within cells, and therefore require drugs that can enter cells and block the receptors in endosomes,” said Bunnett….

…phosphorylase-1 (UPP1) to produce a different form of sugar, ribose, which can fuel cancer cells. Knocking out the UPP1 gene in mice stopped pancreatic cancer cells from using uridine and…

…virus spreads and evolves, a more stable portion, known as the stem, evolves very slowly and is very similar across many different types of the flu virus. By using the…

A molecular machine, which plays an essential ‘cargo’ role in controlling the delivery of proteins to the surface of human cells has been identified using artificial intelligence (AI). The research…

…while selectively targeting the alpha folate receptor (FRα), which is highly expressed in cancer cells compared to normal tissues across a variety of solid tumours. Over 90% of ovarian cancer…

…cells in the retina and transform them into neural-like cells that could ultimately be used to replace cells lost in retinal degeneration. “We have identified two genes that, when expressed…

…the molecule TGF-ß, which is produced by osteosarcoma cells and immune cells in the tumour microenvironment. The presence of TGF-ß dampens the ability of the patient’s immune system to eradicate…