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        New DDW Highlights podcast out now

        25 September 2023

        …also reported on vaccine trials for a number of other conditions, including Nipah virus, rabies and lung cancer. You can listen below, or find The Drug Discovery World Podcast on…

        DDW Highlights: 25 September 2023

        25 September 2023

        …also reported on vaccine trials for a number of other conditions, including Nipah virus, rabies and lung cancer. You can listen below, or find The Drug Discovery World Podcast on…

        Influenza

        Nanoparticle universal flu vaccine enters Phase I trials

        25 September 2023

        Enrolment in a Phase I trial of a new investigational universal influenza vaccine candidate has begun at the National Institutes of Health’s Clinical Center in Bethesda, Maryland, US. The trial…

        CRISPR gene editing

        Partners working to realise the future of genomic medicine

        25 September 2023

        …President and General Manager of Aldevron’s Protein Business Unit. “By combining manufacturing strengths, from day one, IDT clients now can access Aldevron CRISPR proteins which are designed for clinical translation.”…

        siRNA

        Positive preclinical data for siRNA therapy for osteopetrosis

        25 September 2023

        …and open the path to human trials of it’s potentially curative treatment for ADO2. There are currently no approved treatments for this disease and no other treatments currently in clinical…

        This week in drug discovery (11-15 September)  

        22 September 2023

        …generation Covid-19 vaccines clinical trial ICON and the US Biomedical Advanced Research and Development Authority (BARDA) will execute a clinical trial to evaluate the effectiveness of next-generation Covid-19 vaccine candidates….

        Large intestine

        Specialised T cells could offer way to repair the gut barrier

        22 September 2023

        …a useful biomarker for disease progression. Potential drug targets to be investigated Robin Dart, former Wellcome trust funded PhD student at the Crick, postdoctoral clinical research fellow at King’s College…

        Cancer vaccine

        UK scientists prepare for Nipah virus clinical trial

        19 September 2023

        The University of Oxford has revealed that researchers are currently in the advanced stages of preparing for a clinical trial of a Nipah vaccine using the ChAdOx1 vector. The scientists…

        Pluripotent stem cells

        Register now to discover how iPSC derived cells support gene therapy development

        19 September 2023

        A considerable roadblock in the successful triaging of new therapeutics for liver and metabolic related diseases is the reliability and effectiveness of pre-clinical disease models. Methods employing animal models may…

        Covid-19 vaccines

        Partners to execute next generation Covid-19 vaccines clinical trial

        18 September 2023

        ICON, a healthcare intelligence and clinical research organisation, with the US Biomedical Advanced Research and Development Authority (BARDA), part of the Administration for Strategic Preparedness and Response within the US…

        Lungs

        IO Biotech announces data for therapeutic cancer vaccine

        18 September 2023

        IO Biotech, a clinical-stage biopharmaceutical company developing novel, immune-modulating cancer vaccines based on its T-win technology platform, has announced data from a pre-defined interim analysis related to the lung cohort…

        Doctor prepares vaccine

        Phase I trial of next-generation srRNA rabies vaccine

        15 September 2023

        …trials, most notably in oncology and autoimmune disease. “Rabies represents an ideal opportunity to provide rapid clinical validation of our novel vaccine technology given the large exposure-naïve population and established…

        Corporate collaboration

        Collaboration to discover novel targeted radioligand therapies

        15 September 2023

        …discovery times of relevant peptide leads based on affinity screens and/or functional screens. Orano Med will focus on subsequent development of the peptides for clinical use after conjugation with lead-212….

        Cancer cells

        Multi-platform collab to develop innovative oncology therapeutics 

        14 September 2023

        …clinical development and commercialisation of cancer vaccines and TCER therapeutics resulting from the collaboration. Immatics will be responsible for conducting the preclinical studies and a potential Phase I clinical trial…

        Bladder cancer

        Janssen submits EMA filing for bladder cancer treatment 

        14 September 2023

        …metastatic urothelial cancer patients. J Clin Med. 2022;11(15): 4483. Montazeri K & Bellmunt J. Erdafitinib for the treatment of metastatic bladder cancer. Expert Review of Clinical Pharmacology. 2020;13(1):1-6. https://classic.clinicaltrials.gov/ct2/show/NCT03390504 https://www.fda.gov/news-events/press-announcements/fda-approves-first-targeted-therapy-metastatic-bladder-cancer…

        Long Covid

        New post-Covid study links infection and retrovirus 

        13 September 2023

        …Phase II trial evaluating the clinical efficacy of a six-month treatment with temelimab on the improvement of cognitive impairment and/or fatigue in Long Covid patients who are positive for the…

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