Winter 2017/18 Teasers
Drug Discovery World
High-throughput spheroid culture
By Hilary Sherman, Dr Richard M. Eglen & Audrey Bergeron

The cost of drug development is becoming unsustainable, partly due to the high attrition rate of drugs in clinical trials.

The predominant reasons for drug failure are lack of efficacy, poor pharmacokinetics and adverse toxic side-effects not identified during preclinical studies. These challenges of optimising drug discovery mandate a need for improved preclinical models – specifically those that better recapitulate the pathophysiology of the underlying disease, as well as more accurately predict in vivo responses to therapeutic compounds....

You just need to REGISTER - its FREE - to read the rest of this article straight away.