Cell culture is a fundamental technique in both medical research and drug discovery, and for decades, two-dimensional (2D) culture has been the preferred method, due to the ease with which cell monolayers can be induced to proliferate on planar surfaces.

However, early pioneering work in cell culture utilised tissue explants grown in three-dimensions (3D). It was evident that such 3D cultures maintained many attributes that resembled cell growth and differentiation in vivo ..........

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