RESULTS FOR : 'Toxicity'
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Advancing the drug discovery pipeline with early stage In vitro ADME and toxicity testing

With increasing pressures on pharmaceutical companies to develop new, effective therapeutics across the board, and keep the costs of development down, the drug discovery industry needs to ensure that its standard processes and procedures are as streamlined and effective as possible.

Microtissues for in vitro toxicity assessment: Cost effective and in vivo relevant toxicology tools

Conventional two-dimensional (2D) cell models (adherent cells grown on cell culture plates or cells in suspension) are limited in their abilities to accurately predict clinical toxicity since they lack the fundamental complexity of in vivo tissue environments.

An automated approach to solving Pharma's cardiac toxicity conundrum. Spring 13

The pharmaceutical industry is facing ever-growing difficulties in developing new drugs and bringing them to market1,2. Many factors stand in the way of R&D productivity, not least of which are shrinking budgets. Yet one of the most pressing challenges continues to be the issue of ensuring that new drug candidates have an acceptable safety profile.

The Sooner the Better: Utilising biomarkers to eliminate drug candidates with cardiotoxicity in preclinical development.

The rapidly escalating costs of drug development is causing the biopharmaceutical industry to focus its R&D efforts on identifying new technologies and methods that can predict the safety and efficacy of new compounds as early as possible in the drug development process. Today, only one in 11 compounds advance from first-in-man studies to regulatory approval and these late-stage failures mainly caused by safety issues exact a heavy toll on the biopharmaceutical industry as the cost of clinical trials is extremely expensive, legal liability is of concern and companies are under great scrutiny by investors

BlueScreen HC - A Luminescence Based, High-Throughput, In Vitro Genotoxicity Assay

The BlueScreen HCTM genotoxicity assay from Gentronix Ltd. uses a human-derived, p53-competent, TK6 cell line to host a luminescence-based reporter system that exploits the proper regulation of the GADD45a gene. GADD45a plays an important role in mediating the cellular response to genotoxic stress.

METABONOMICS a generic platform for the investigation of drug toxicity, altered gene function and disease processes. Summer 04

Metabonomics can offer one of the most complete solutions to tackling one of the pharmaceutical industry’s biggest problems – attrition.This article discusses the scope and uses of metabonomics in different areas of the drug discovery and development process.

COX-2 inhibitor toxicity warning shot over pharma's bow. Spring 05

Human beings are complex gene machines that rely on the intricate interplay of ~25,000 genes to impart biological function. Genomic function is affected by genetic variability and environmental factors, giving rise to considerable functional heterogeneity in the human population. Drug responsiveness and side-effects can vary from person to person, as seen in the recent observation of COX-2 inhibitor toxicity in a subset of prescribed users.

Multiparametric Live Cell Cytotoxicity using The Operetta

Key Features • Automated image acquisition using the Operetta™ High Content Screening System • Data analysis using the versatile Harmony™ Software • Image-based quantification of drug induced cytotoxic effects on hepatocytes

Evaluation of Compound Cytotoxicity using The Opera

Key Features • Automated confocal image acquisition of live cells using the Opera™ High Content Screening system • Image analysis using Acapella™ LiveDead Script and CellRegionAnalysis Script • Quantification of characteristic changes following a toxic insult

Is amyloid-related toxicity an inevitable consequence of ageing? Spring 08

Amyloid-related toxicity need not necessarily be the inevitable consequence of ageing, if some of the new drug discovery strategies to treat neurodegenerative and other ageing-related diseases succeed in the clinic.