RESULTS FOR : 'Rational drug design'
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How neutron science has enabled innovation in drug design and delivery.

Meeting global health challenges, from cancer to viral infections, requires a profound understanding of living processes – not just at the level of cells but right down at the molecular level. And designing the most efficient therapeutics requires an in-depth understanding of the disease.

Rules for drug discovery: can simple property criteria help you to find a drug?

The years since the publication of Lipinski’s Rule of Five (Ro5)1 in 1997 have seen the growth of a minor industry, dedicated to generating new ‘rules’ for drug discovery. Fuelled by what Kenny and Montanari have termed “Ro5 envy”2, these rules are usually based on simple calculated compound characteristics and define criteria for the selection of compounds in drug discovery. But, can a generic rule be used to reliably select compounds for drug discovery?