RESULTS FOR : 'Phenotypic'
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Phenotypic Drug Discovery: striving towards the highest level of biological relevance.

Phenotypic drug discovery (PDD) implies screening where the molecular mechanism of action is not assumed and does not require knowledge of the molecular target.

High Throughput Flow: a high content platform for phenotypic screening?

Flow cytometry has many of the technology attributes (eg multi-parameter analysis of cell suspensions) needed when attempting to profile a phenotypic drug response. However, for flow cytometry to be considered the phenotypic drug screening platform of choice it needs to interface with the real screening world, ie be able to support higher throughput and to acquire low sample volumes from high density microplates.

Opportunities for phenotypic screening in drug discovery.

Renewed awareness of the value of phenotypic screening to drug discovery1-5 creates many new opportunities to increase drug discovery success and productivity. These opportunities include identification of translational phenotypic biomarkers, development of new assays that translate to human disease and refinement of paradigms to successfully execute phenotypic drug discovery (PDD).

precise phenotypic anchoring for drug target identification, validation and biomarker discovery using an advanced SYSTEMS BIOLOGY approach. Summer 04

The pharmaceutical industry has not seen the hoped-for productivity gains from the various omics datastreams over the last decade.This article discusses how systems biology can exploit the natural interlinkages between these datastreams and put in place a powerful system for modern therapeutic development.